Functionalized MCM-48 as Carrier for In Vitro Controlled Release of an Active Biomolecule, L-Arginine

Abstract

The present chapter describes the synthesis, characterizations, and application of MCM-48 functionalized by an inorganic moiety, as a carrier. MCM-48 functionalized by 12-tungstophophoric acid (TPA) (TPA-MCM-48) and L-arginine was loaded into pure as well as functionalized MCM-48. Both the materials were characterized by various physicochemical techniques and evaluated for in vitro release of L-arginine at body temperature under different conditions. A study on release kinetics was carried out using first-order release kinetic model, while the mechanism were by Higuchi model. Further, to see the influence of TPA on release rate, release profile obtained from pure and functionalized MCM-48 was compared.

Mesoporous silica nanocarriers as drug delivery systems for anti-tubercular agents: a review

“…The use of mesoporous materials for drug delivery began in 2001 with the synthesis of a silica-based mesoporous material MCM-41 for the delivery of ibuprofen [56]. MSNs have unique properties which give them an edge over conventional drugs delivery systems, which includes: Controllable pore morphology and structures with large surface areas (700–1000 m 2 g −1 ) and pore volumes (0.6–1 cm 3 g −1 ) are essential for the loading and release of an extensive range of drug molecules [57,58].…”