Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Varès, Guillaume; Jallet, Vincent; Matsumoto, Yoshitaka; Rentier, Cédric; Takayama, Kentaro; Sasaki, Tomohiro; Hayashi, Yoshio; Kumada, Hiroaki; Sugawara, Hirotaka

doi:10.1016/j.nano.2020.102195

Cited by 33 publications

(32 citation statements)

References 59 publications

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“…On the other hand, new high LET radiation therapy modalities have emerged as contributors to overcome CSC-related resistance, such as boron-neutron capture therapy (BNCT) and carbon-ion particle therapy [ 188 , 189 ], used alone or in combination with other targeted treatments like PARP inhibitors [ 190 , 191 , 192 , 193 ]. Since BNCT releases high-LET radiation, it should provide RBE and a lower oxygen enhancement ratio (OER), compared to conventional RT.…”

Section: Radiocurability and Radiation Therapy Resistancementioning

confidence: 99%

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

Olivares-Urbano

Griñán‐Lisón

Marchal

et al. 2020

Cells

147

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Radiotherapy (RT) is a modality of oncologic treatment that can be used to treat approximately 50% of all cancer patients either alone or in combination with other treatment modalities such as surgery, chemotherapy, immunotherapy, and therapeutic targeting. Despite the technological advances in RT, which allow a more precise delivery of radiation while progressively minimizing the impact on normal tissues, issues like radioresistance and tumor recurrence remain important challenges. Tumor heterogeneity is responsible for the variation in the radiation response of the different tumor subpopulations. A main factor related to radioresistance is the presence of cancer stem cells (CSC) inside tumors, which are responsible for metastases, relapses, RT failure, and a poor prognosis in cancer patients. The plasticity of CSCs, a process highly dependent on the epithelial–mesenchymal transition (EMT) and associated to cell dedifferentiation, complicates the identification and eradication of CSCs and it might be involved in disease relapse and progression after irradiation. The tumor microenvironment and the interactions of CSCs with their niches also play an important role in the response to RT. This review provides a deep insight into the characteristics and radioresistance mechanisms of CSCs and into the role of CSCs and tumor microenvironment in both the primary tumor and metastasis in response to radiation, and the radiobiological principles related to the CSC response to RT. Finally, we summarize the major advances and clinical trials on the development of CSC-based therapies combined with RT to overcome radioresistance. A better understanding of the potential therapeutic targets for CSC radiosensitization will provide safer and more efficient combination strategies, which in turn will improve the live expectancy and curability of cancer patients.

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Section: Radiocurability and Radiation Therapy Resistancementioning

confidence: 99%

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

Olivares-Urbano

Griñán‐Lisón

Marchal

et al. 2020

Cells

147

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“…One of the problems that nuclear doctors face when using neutron irradiation is the lack of a quantitative imaging method for evaluation of the boron concentration. To solve this problem and to achieve selective tumor accumulation and reduced toxicity, several approaches have been applied: (1) coating of boronated porphyrins with biocompatible poly(lactide-co-glycolide)monomethoxypoly(polyethylene-glycol) (PLGA-mPEG) micelles [43], functionalizing mesoporous silica nanoparticles [51], labeling MMT1242 with a nitrobenzoxadiazole frame, which emits green-yellow fluorescence [52], and so on, in general, labeling vesicles by different fluorophores or molecules with fluorescence properties [53,54]. Ion microscopy may also be used to evaluate the distribution of isotope 10 B, as was shown in two brain tumor models, the 9L rat gliosarcoma and the F98 rat glioma [55].…”

Section: Third-generation Boron Compoundsmentioning

confidence: 99%

Boron neutron capture therapy: Current status and future perspectives

Дымова

Taskaev

Richter

et al. 2020

Cancer Communications

191

173

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The development of new accelerators has given a new impetus to the development of new drugs and treatment technologies using boron neutron capture therapy (BNCT). We analyzed the current status and future directions of BNCT for cancer treatment, as well as the main issues related to its introduction. This review highlights the principles of BNCT and the key milestones in its development: new boron delivery drugs and different types of charged particle accelerators are described; several important aspects of BNCT implementation are discussed. BCNT could be used alone or in combination with chemotherapy and radiotherapy, and it is evaluated in light of the outlined issues. For the speedy implementation of BCNT in medical practice, it is necessary to develop more selective boron delivery agents and to generate an epithermal neutron beam with definite characteristics. Pharmacological companies and research laboratories should have access to accelerators for large‐scale screening of new, more specific boron delivery agents.

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“…In clinical settings, these reagents are administered by intravenous injection into patients. Nanoformulated boron reagents such as boron-loaded liposomes, polymers and silica nanoparticles have been developed [ 62 , 63 , 64 , 65 ].…”

Section: Irradiation Other Than X-rays and Development Of Various mentioning

confidence: 99%

Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy

et al. 2020

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While conventional radiation therapy uses white X-rays that consist of a mixture of X-ray waves with various energy levels, a monochromatic X-ray (monoenergetic X-ray) has a single energy level. Irradiation of high-Z elements such as gold, silver or gadolinium with a synchrotron-generated monochromatic X-rays with the energy at or higher than their K-edge energy causes a photoelectric effect that includes release of the Auger electrons that induce DNA damage—leading to cell killing. Delivery of high-Z elements into cancer cells and tumor mass can be facilitated by the use of nanoparticles. Various types of nanoparticles containing high-Z elements have been developed. A recent addition to this growing list of nanoparticles is mesoporous silica-based nanoparticles (MSNs) containing gadolinium (Gd–MSN). The ability of Gd–MSN to inhibit tumor growth was demonstrated by evaluating effects of irradiating tumor spheroids with a precisely tuned monochromatic X-ray.

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Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

Cited by 33 publications

References 59 publications

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

CSC Radioresistance: A Therapeutic Challenge to Improve Radiotherapy Effectiveness in Cancer

Boron neutron capture therapy: Current status and future perspectives

Studies on the Exposure of Gadolinium Containing Nanoparticles with Monochromatic X-rays Drive Advances in Radiation Therapy

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