Functionalized Mesoporous Thin Films for Biotechnology

Abstract

Mesoporous materials bear great potential for biotechnological applications due to their biocompatibility and versatility. Their high surface area and pore interconnection allow the immobilization of molecules and their subsequent controlled delivery. Modifications of the mesoporous material with the addition of different chemical species, make them particularly suitable for the production of bioactive coatings. Functionalized thin films of mesoporous silica and titania can be used as scaffolds with properties as diverse as promotion of cell growth, inhibition of biofilms formation, or development of sensors based on immobilized enzymes. The possibility to pattern them increase their appeal as they can be incorporated into devices and can be tailored both with respect to architecture and functionalization. In fact, selective surface manipulation is the ground for the fabrication of advanced micro devices that combine standard micro/nanofluids with functional materials. In this review, we will present the advantages of the functionalization of silica and titania mesoporous materials deposited in thin film. Different functional groups used to modify their properties will be summarized, as well as functionalization methods and some examples of applications of modified materials, thus giving an overview of the essential role of functionalization to improve the performance of such innovative materials.

Remote Temperature-Responsive Parafilm Dermal Patch for On-Demand Topical Drug Delivery

“…Moreover, compared with the no-heat group, the mild heat treatment group showed better and earlier recovery from the wound. Therefore, it can be concluded that mild temperature can stimulate the tissue to undergo the first stage of the repair process [ 28 , 37 , 38 , 39 ]. The results also demonstrated that the drug-loaded PP film significantly impacted the dermal healing process, and this effect was improved using remote mild heating.…”

Nano-enabled antimicrobial thin films: design and mechanism of action

“… 58 For example, antibacterial agents incorporated mesoporous titania thin films characterized by controlled drug release, high pore volume and high surface area which make them ideal drug loading site is among the promising materials which can be coated onto the medical devices. 59 Atefyekta et al reported titanium oxide-based mesoporous titania thin film loaded with the antimicrobial agents (vancomycin, gentamicin, and daptomycin) in its pore volume. The thin film is characterized by decreased biofilm attachment to its surface and tunable antibacterial loading observed to be increased with increasing pore volume; thus highly contribute to host tissue growth and reduced biomaterial associated infections.…”

Printing of In Situ Functionalized Mesoporous Silica with Digital Light Processing for Combinatorial Sensing

“…[ 5 ] Among other materials, modified porous support materials are suitable for high‐throughput applications due to their high specific surface area allowing high loading densities of active components. [ 6 ] Mesoporous inorganic and organic–inorganic hybrid films haveattracted growing interest due to their versatile potential in biotechnological applications, [ 7 ] electrochemical energy storage and conversion, [ 8 ] catalysis [ 9 ] as well as sensing. [ 10 ] Fabrication of mesoporous silica films is in most cases based on Evaporation‐Induced Self‐Assembly (EISA).…”