Functionalized Micellar Systems for Cancer Targeted Drug Delivery

Sutton, Damon; Nasongkla, Norased; Blanco, Elvin; Gao, Jinming

doi:10.1007/s11095-006-9223-y

Cited by 521 publications

(382 citation statements)

References 122 publications

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“…[486] Despite the bulky structure of antibodies, they can equip the nanoparticles to specifically bind to their targets, even if they are conjugated in low densities at the surface of nanoparticles. [488] Antibodies were firstly used in 1980s to modify liposome nanoparticle surfaces wherein the antigens on the target cells were recognized. [489] Since the first approved antibody in 1986, [490] muromonab-CD3, numerous antibody platforms such as chimeric, murine, and humanized antibodies have been developed with more than 30 types of them being approved for clinical uses.…”

Section: Antibodiesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Antibodiesmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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“…They are imperative for cancer therapeutic applications due to their in vivo stability, ability to solubilize water-insoluble drugs, prolongation of blood circulation time, and small size of 10–100 nm [86]. Folic acid-conjugated, PTX-loaded polymeric composite micelles targeted and inhibited tumor growth and caused cell apoptosis of U14 cervical cancer tumors both in vitro and in vivo [87].…”

Section: Systemic Versus Localized Drug Delivery Systemsmentioning

confidence: 99%

Possible role of nanocarriers in drug delivery against cervical cancer

Gupta

2017

Nano Reviews & Experiments

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Introduction: Cervical cancer is the second most common cancer and the largest cancer killer among women in most developing countries including India. Although, various drugs have been developed for cervical cancer, treatment with these drugs often results in a number of undesirable side effects, toxicity and multidrug resistance (MDR). Also, the outcomes for cervical cancer patients remain poor after surgery and chemo radiation. Methods: A literature search (for drugs and delivery systems against cervical cancer) was performed on PubMed and through Google. The present review discuss about various methods including its current conventional treatment with special reference to recent advances in delivery systems encapsulating various anticancer drugs and natural plant products for targeting towards cervical cancer. The role of photothermal therapy, gene therapy and radiation therapy against cervical cancer is also discussed. Results: Systemic/targeted drug delivery systems including liposomes, nanoparticles, hydrogels, dendrimers etc. and localized drug delivery systems like cervical patches, films, rings etc. are safer than the conventional chemotherapy which has further been proved by the several drug delivery systems undergoing clinical trials. Conclusion: Novel approaches for the aggressive treatment of cervical cancer will optimistically result in decreased side effects as well as toxicity, frequency of administration of existing drugs, to overcome MDR and to increase the survival rates.

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“…Singlet oxygen quantum yield values in water were determined under ambient conditions using the chemical method with ADMA as a singlet oxygen quencher in water using Equation (2). [19] Std Std abs Std abs…”

Section: Singlet Oxygen Quantum Yield (ф δ )mentioning

confidence: 99%

“…[1] Polymer micelles also have the ability to solubilize water insoluble anticancer drugs such as porphyrins which are a subject of the current work. [2] The polymeric micelles of interest in this work are the Pluronic triblock copolymers which are composed of poly(ethylene oxide) (PEO) and poly(propylene oxide) (PPO) with a PEO-PPO-PEO structure (Scheme 1). [3] The PEO and PPO segments on the micelles act, respectively, as hydrophilic corona and hydrophobic core.…”

Section: Introductionmentioning

confidence: 99%