Functionalized nanoscale β-1,3-glucan to improve Her2+ breast cancer therapy: In vitro and in vivo study

Nasrollahi, Zahra; Mohammadi, Shahla Roudbar; Mollarazi, Esmail; Yadegari, Mohammad Hossein; Hassan, Zuhair Mohammad; Talaei, Fatemeh; Dinarvand, Rassoul; Akbari, Hassan; Atyabi, Fatemeh

doi:10.1016/j.jconrel.2015.01.014

Cited by 30 publications

(15 citation statements)

References 37 publications

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“…21 Since glucan is nearing use in clinical practice, attention has returned to the potential role in implementing changes in the hematopoietic system and more and more studies describe positive effects of glucan in cancer treatment. [22][23][24][25][26] The positive effects of glucan supplementation are well established with over 8,000 published studies. This knowledge results in more and more common use of glucan in prevention and the direct treatment of many diseases.…”

Section: Discussionmentioning

confidence: 99%

Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Richter¹,

Vlastimil²,

Pohorska³

et al. 2016

IJCEMS

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Glucan is the most studied immunomodulator. Among its properties, effects on cancer are the closest to clinical use. In our study, we evaluated the effects of short-term supplementation with glucan on NK cells in patients recovering from different types of cancer treatment. NK cells represent a distinct sub-population of lymphocytes endowed with the capacity to kill tumor cells without prior sensitization and form one of the most important defense mechanisms against cancer. To measure the numbers of NK cells, flow cytometer measuring four colors was used. Using a double-blind, placebo-controlled clinical trial, we found that adding glucan to the diet strongly increased the number of NK cells in blood.

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Section: Discussionmentioning

confidence: 99%

Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Richter¹,

Vlastimil²,

Pohorska³

et al. 2016

IJCEMS

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“…Curdlan can be used as a modifier to produce composite scaffolds or wound dressings with enhanced mechanical and biological properties [ 99 , 100 ], but is not soluble in water (although it can be solubilized in water with salt). Finally, this exopolysaccharide has antitumoral properties [ 101 ].…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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“…Human serum albumin (HSA) has been shown to be biodegradable, biocompatible, and nonimmunogenic, and it has been used extensively as a protein carrier. HSA may protect drug molecules from degradation, increase water solubility, increase drug absorption by facilitating diffusion through epithelium, change the drug tissue distribution profile and pharmacokinetic, and/or improve intracellular penetration and distribution [4][5][6][7][8][9][10]. Albumin-bound nanoparticles can facilitate drug accumulation in tumors by a well-known passive targeting mechanism called the enhanced permeability and retention (EPR) effect.…”

Section: Introductionmentioning

confidence: 99%

Preparation of human serum albumin nanoparticles using a chemometric technique

et al. 2017

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Human serum albumin (HSA), a versatile protein carrier for drug delivery, is an ideal material to fabricate nanoparticles for drug delivery systems. These nanoparticles can accumulate in tumor interstitium due to the enhanced permeability and retention effect. The most important characteristics of HSA nanoparticles are particle size, shape, and zeta potential. A chemometric approach was applied for HSA nanoparticles' size optimization in this study. The effects of three experimental parameters; pressure (P) or power, organic solvent volume (V), and time (T), were investigated under sonication and high-pressure homogenization, using multivariate analysis. The trials were performed based on the Box-Behnken experimental design. The criteria for the appraisal of the descriptive ability of a multinomial were R 2 = 0.819, standard error = 20.420, and F-ratio = 19.550. The method was optimized with respect to the nanoparticles' size as a response. The Box-Behnken experimental design was applied to optimize and trial the robustness of the HSA nanoparticle preparation method.

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Functionalized nanoscale β-1,3-glucan to improve Her2+ breast cancer therapy: In vitro and in vivo study

Cited by 30 publications

References 37 publications

Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Effects of β-Glucan on Natural Killer Cells in Patients Recovering from Cancer Treatment: Clinical Trial

Microbial Exopolysaccharides as Drug Carriers

Preparation of human serum albumin nanoparticles using a chemometric technique

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