Functionalized phosphorylated cellulose microspheres: Design, characterization and ciprofloxacin loading and releasing properties

Wu, Simei; Gong, Yaqi; Liu, Shilin; Pei, Ying; Luo, Xiaogang

doi:10.1016/j.carbpol.2020.117421

Cited by 31 publications

(8 citation statements)

References 43 publications

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“…The antibiotic ciprofloxacin was then loaded into the microspheres with an encapsulation efficiency of 100%. The data relating to its release from our microspheres are in line with those of other authors [ 36 , 37 , 38 ]. However, the different trend in terms of release time and quantity of drug released is probably due to the different affinity of ciprofloxacin towards the materials of which the different types of microspheres are made.…”

Section: Discussionsupporting

confidence: 92%

Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

et al. 2022

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This article describes the preparation, characterization, and performance evaluation of functional microspheres useful for the release of ciprofloxacin. The particles were obtained using D-mannose, a natural aldohexose sugar, and resveratrol, a powerful antioxidant. In particular, the above compounds were initially converted into D-mannose carboxylate and resveratrol methacrylate and, therefore, subjected to an esterification reaction. The resulting product was used for the preparation of the microspheres which were characterized by light scattering, FT-IR spectrophotometry and scanning electron microscopy (SEM). Subsequently, their degree of bloating was evaluated at pH 1.2 to simulate the pH of the stomach, at pH 6.8 and pH 7.4 to mimic the intestinal environment. The antibiotic ciprofloxacin was then loaded into the microspheres, with an encapsulation efficiency of 100%. The cumulative amount of drug released was 55% at pH 6.8 and 99% at pH 7.4. The tests conducted to evaluate the antibacterial activity demonstrated the ability of the microspheres obtained to inhibit the growth of Escherichia coli. The antioxidant efficacy, due to the presence of resveratrol in their structure, was confirmed using rat liver microsomal membranes. The results obtained have highlighted how the microspheres based on D-mannose and resveratrol can be considered promising multifunctional vectors useful in the treatment of intestinal and urinary infections.

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Section: Discussionsupporting

confidence: 92%

Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

et al. 2022

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“…Phosphorylated CNF is a new type of chemically modified CNF, which is characterized by high charge density, flame retardancy, and dispersion stability over a wide pH range. Phosphorylated CNF has been applied to fabricate flame-retardant films and porous materials, − drug delivery matrices, and uranium adsorbents . The phosphorylation conditions are critical to efficiently manufacture phosphorylated CNF.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Quantification of Diverse Functional Groups on Phosphorylated Nanocellulose Surfaces

2021

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Phosphorylated cellulose nanofiber (CNF) is attracting attention as a newly emerged CNF with high functionality. However, many structural aspects of phosphorylated CNF remain unclear. In this study, we investigated the chemical structures and distribution of ionic functional groups on the phosphorylated CNF surfaces via liquid-state nuclear magnetic resonance measurements of colloidal dispersion. In addition to the monophosphate group, polyphosphate groups and cross-linked phosphate groups were introduced in the phosphorylated CNFs. The proportion of polyphosphate groups increased as the phosphorylation time increased, reaching ∼30% of all phosphate groups. Only a small amount of cross-linked phosphate groups existed in the phosphorylated CNF after a prolonged reaction time. Furthermore, phosphorylation of cellulose using urea and phosphoric acid was found to be regioselective at the C2 and C6 positions. There existed no significant difference between the surface degrees of substitution at the C2 and C6 positions of the phosphorylated CNFs.

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“…1a and e), which was smaller than that reported previously. 28 The pore size range was from 20 to 100 nm (Fig. 1c), and the pore volume was 0.739 cm 3 g −1 (Fig.…”

Section: Characterization Of Morphology and Physical Propertiesmentioning

confidence: 96%

A design approach to eliminate the toxic effect of insecticides to ensure human safety

Chang

Zhang

et al. 2022

Green Chem.

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Functionalized phosphorylated cellulose microspheres: Design, characterization and ciprofloxacin loading and releasing properties

Cited by 31 publications

References 43 publications

Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

Multifunctional Microspheres Based on D-Mannose and Resveratrol for Ciprofloxacin Release

Distribution and Quantification of Diverse Functional Groups on Phosphorylated Nanocellulose Surfaces

A design approach to eliminate the toxic effect of insecticides to ensure human safety

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