A functionally graded material (FGM) of polyetheretherketone (PEEK)-hydroxyapatite (HA) with a symmetrical three-layer structure containing 8.7, 2.6 and 8.7 vol% HA, respectively, is successfully fabricated by hot pressing and evaluated by scanning electron microscopy and tensile testing. A good bonding between the HA particles and the PEEK matrix is achieved by virtue of an in situ method in fabricating each PEEK-HA composite layer. There are no apparent microcracks and microscopic interfaces within each layer of the FGM. The symmetrical PEEK-HA FGM does not fall apart or delaminate during loading with a tensile strength of 86.2 MPa, and its fracture energy is 56.5 kJ/m 2 . Furthermore, in vivo bioactivity of the FGM sample is also evaluated, showing that it has sound biocompability and bioactivity. Accordingly, the FGM in the future may be a promising biomaterial to be used as replacement implant of human bone through a proper design to balance mechanical properties and bioactivity.