Functionally graded hydroxyapatite coatings doped with antibacterial components

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…The analysis of the coating's cross-section revealed a decreased crystallinity as well as a distribution of nano-sized (10-50 nm) silver particles from the coating/substrate interface to top surface. 1110 A functionally graded HA/PMMA biocomposite was developed based on sedimentary HA distributions in a PMMA viscous fluid, using a centrifuge to avoid stress convergence on the interface. The stress-strain curves of this biocomposite showed sufficient strength for biomedical applications along with the relaxation of brittleness and fragility.…”

Cytotoxicity of a new antimicrobial coating for surgical screws: an in vivo study

“…(4,18) Such materials include silver and silver compounds, selenium and antimicrobial peptides. (5,(17)(18)(19)(20) Silver-or selenium-coated implants are effective (20,21) but expensive; furthermore, the use …”

“…Although antibiotic-impregnated implants have been reported to successfully prevent infection in orthopaedic patients, there are concerns that the use of such implants may lead to increased bacterial antibiotic resistance. (3)(4)(5) Implant infection commences when bacteria adhere to the implant and reproduce to form a biofilm (6) that will, in turn, promote antibiotic resistance; this challenges the immune system and triggers the need for higher doses of antibiotics. (7) Sessile bacteria in biofilms are difficult to identify and treat.…”

A Silver Ion-doped Calcium Phosphate-based Ceramic Nanopowder-coated Prosthesis Increased Infection Resistance

“…Such materials include antibiotics [2,3,11,12], such as gentamicin and vancomycin, or silver and silver-containing compounds [4-7, 9-11, 16, 27]. The mechanism of the antimicrobial action of silver ions is closely related to their interaction with thiol (sulfhydryl) groups [20].…”