Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice

Moisenovich, M. M.; Куликов, Д. А.; Arkhipova, A. Yu.; Malyuchenko, N. V.; Kotlyarova, M. S.; Гончаренко, А. В.; Куликов, А. В.; Машков, А Е; Агапов, И. И.; Палеев, Ф. Н.; Svistunov, Andrey; Kirpichnikov, Mikhaǐl P.

doi:10.17116/terarkh2015871266-72

Ter. arkh.

2015

DOI: 10.17116/terarkh2015871266-72

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Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice

M. M. Moisenovich

Д. А. Куликов²,

A. Yu. Arkhipova

et al.

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Cited by 8 publications

(1 citation statement)

References 19 publications

(26 reference statements)

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“…Bombyx mori silk fibroin has a number of unique properties, such as mechanical strength, biocompatibility, bioresorption, and availability. Several studies [6,7] showed that fibroin is a good substrate for the adhesion and proliferation of different cell types and can be used for creating scaffolds with different structures and desired shape and size.…”

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confidence: 99%

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Moisenovich

Куликов

Гончаренко

et al. 2017

Dokl Biochem Biophys

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confidence: 99%

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Moisenovich

Куликов

Гончаренко

et al. 2017

Dokl Biochem Biophys

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Effects of fibroin microcarriers on inflammation and regeneration of deep skin wounds in mice

Arkhipova

Носенко

Malyuchenko

et al. 2016

Biochemistry Moscow

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The process of tissue regeneration following damage takes place with direct participation of the immune system. The use of biomaterials as scaffolds to facilitate healing of skin wounds is a new and interesting area of regenerative medicine and biomedical research. In many ways, the regenerative potential of biological material is related to its ability to modulate the inflammatory response. At the same time, all foreign materials, once implanted into a living tissue, to varying degree cause an immune reaction. The modern approach to the development of bioengineered structures for applications in regenerative medicine should be directed toward using the properties of the inflammatory response that improve healing, but do not lead to negative chronic manifestations. In this work, we studied the effect of microcarriers comprised of either fibroin or fibroin supplemented with gelatin on the dynamics of the healing, as well as inflammation, during regeneration of deep skin wounds in mice. We found that subcutaneous administration of microcarriers to the wound area resulted in uniform contraction of the wounds in mice in our experimental model, and microcarrier particles induced the infiltration of immune cells. This was associated with increased expression of proinflammatory cytokines TNF, IL-6, IL-1β, and chemokines CXCL1 and CXCL2, which contributed to full functional recovery of the injured area and the absence of fibrosis as compared to the control group.

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Osteogenic differentiation of mouse bone marrow stromal cells on fibroin microcarriers

Гончаренко

Kotlyarova

Мойсенович

et al. 2017

Dokl Biochem Biophys

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Fundamental bases for the use of silk fibroin-based bioresorbable microvehicles as an example of skin regeneration in therapeutic practice

Cited by 8 publications

References 19 publications

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Regeneration of jejunal wall defect using an implant based on silk fibroin fibers

Effects of fibroin microcarriers on inflammation and regeneration of deep skin wounds in mice

Osteogenic differentiation of mouse bone marrow stromal cells on fibroin microcarriers

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