Fundamental Biomechanics in Bone Tissue Engineering

Wang, X.; Nyman, Jeffry S.; Dong, Xuesong; Leng, Huijie; Reyes, M.

doi:10.2200/s00246ed1v01y200912tis004

Cited by 62 publications

(59 citation statements)

References 650 publications

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“…However, the bioactive properties of xenografts are weaker than allografts and autografts. To improve xenografts, a new treatment technique has been introduced for bone or tissue repair called bone tissue engineering -a procedure to regenerate damaged bone by implanting cells, proteins and scaffold to provide mechanical support for gap areas [122]. Bone substitute morphology has many forms, such as a compact and porous structure.…”

Section: Chitosan/gelatin/hydroxyapatite Scaffolds As Potential Biomamentioning

confidence: 99%

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

Perchyonok¹,

Grobler²,

Basson³

et al. 2016

Nanomaterials and Regenerative Medicine

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Section: Chitosan/gelatin/hydroxyapatite Scaffolds As Potential Biomamentioning

confidence: 99%

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

Perchyonok¹,

Grobler²,

Basson³

et al. 2016

Nanomaterials and Regenerative Medicine

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“…Uniform seeding of cells within a scaffold is difficult to control, but is a fundamental step in generating functional tissues [64]. Various techniques are used to distribute cells uniformly throughout a scaffold.…”

Section: Implanting Cells Within a Scaffoldmentioning

confidence: 99%

“…Various techniques are used to distribute cells uniformly throughout a scaffold. One technique called "static seeding" involves pipetting a cell suspension into a gel-like, or porous scaffold [64]. A second method called "perfusion seeding" has also been proposed.…”

Section: Implanting Cells Within a Scaffoldmentioning

confidence: 99%

Stem Cell-Based Tissue Engineering for Bone Repair

Damaraju

Duncan

2014

Tissue Engineering

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Culturing cells in 3D scaffolds can help model a physiological process. The property of the substrate used for such scaffolds has been shown to modify and determine stem cell lineage. Using this knowledge, in-vitro 3D stem cell culture models with ex-vivo bone tissue investigations can offer insight and inspiration for the development of novel therapies for bone defects. Although many different scaffolds have been created for bone tissue repair, in situ cell level mechanics are not always given consideration as the main design target. Overall, the ideal tissue engineering solution to bone regeneration would incorporate cells of osteogenic potential into a synthetic bone scaffold in order to reduce the need for external factors added such as drugs or growth factors. Attention to the mechanical aspects of the bone to be studied as well as the cells to be placed within the scaffold is fundamental. In this chapter, we will explore studies investigating the role of cell communication in bone mechanosensing, including the roles of different bone cells in the process of bone adaptation and repair, and the use of this knowledge in creating a novel tissue engineering strategy for the repair of acute bone defects.

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“…To quantify the mechanical properties of a viscoelastic material we need to take into account stress relaxation and creep. Stress relaxation is the reduction in tension in a material subject to a constant strain, while creep is the gradual increase in the strain of a material subject to a constant load 16 . Viscoelastic behaviour is described using three variables: storage modulus, E', loss modulus, E" and loss tangent, tan δ).…”

Section: Viscoelasticitymentioning

confidence: 99%

“…Using the theory of beam bending and assuming that bone has an elastic linear behaviour, we calculate the stress and strain in a flexion test at three points in the following manner 10,16,20 :…”

Section: Mechanical Tests Of Bendingmentioning

confidence: 99%

Biomecánica y hueso (I): Conceptos básicos y ensayos mecánicos clásicos

Guede

González

Caeiro

2013

Rev Osteoporos Metab Miner

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SummaryThe principals of classical mechanics are applied to the study of the resistance of materials to fracture when subject to a certain load. Bone has been, for a long time, the object of study in the field of mechanics in order to understand and resolve problems of fracture associated with deficient mechanical behaviour which may exist due to factors such as age or certain pathologies. The great quantity of specific vocabulary used in biomechanics, derived as it is from the terminology of mechanical engineering, makes it very difficult, on occasion, for researchers specialising in bone and mineral metabolism to interpret information available in the literature on the resistance of bone. The objective of this work is to describe as briefly and concisely as possible the main concepts and fundamental principles used in biomechanics, focused on their application to bone tissue. In addition, the main mechanical trials carried out on whole bones or on samples of trabecular or cortical bone are reviewed.

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Fundamental Biomechanics in Bone Tissue Engineering

Cited by 62 publications

References 650 publications

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

Temporomandibular Disorders and BIO-IPNs: in vitro approach to find molecular solution to biological problem

Stem Cell-Based Tissue Engineering for Bone Repair

Biomecánica y hueso (I): Conceptos básicos y ensayos mecánicos clásicos

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