Fundamental studies of adrenal retinoid-X-receptor: Protein isoform, tissue expression, subcellular distribution, and ligand availability

Cheng, Behling; Al-Shammari, Fatema; Ghader, Isra’a A.; Sequeira, Fatima; Thakkar, Jitendra; Mathew, T.C.

doi:10.1016/j.jsbmb.2017.03.002

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“…Thus, adrenocortical cells develop effective mechanisms with which cholesterol is taken up from plasma lipoproteins for steroidogenesis, and excessive cholesterol is either stored in cytosolic lipid droplets or released back to circulation via an ATPbinding cassette (ABC) transporter-mediated process, commonly referred as "cholesterol efflux." Rat adrenal cortex expressesliver-X-receptor (LXR) [8] and retinoid-X-receptors (RXR) α and β [9]. LXR/RXR heterodimer enhances the expression of ABCA1 and ABCG1 [10].…”

Section: Discussionmentioning

confidence: 99%