Fundamentals of Cybernetics

Lerner, A. Ya.

doi:10.1007/978-1-4684-1704-3

Cited by 19 publications

(4 citation statements)

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“…4c) and similar figures have been used to demonstrate the establishment of equilibria in populations of predator and prey (Gause, 1934, Lotka, 1956 and mechanical systems (Lerner, 1972). By plotting R % against change in R %, the central intercept where R = 100 % and change in R % = 0 represents the equilibrium point.…”

Section: Experiments With Various Growth Inhibitorsmentioning

confidence: 97%

The kinetics of growth control in a colonial hydroid

Stebbing

1981

J. Mar. Biol. Ass.

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It is suggested that the cumulative view of growth in which some index of biomass is plotted against time tends to obscure temporal variations in the growth process that might provide evidence of how it is controlled. Experiments with the colonial hydroid Campanularia flexuosa show that the action of a growth control mechanism can be demonstrated by considering changes in specific rates of growth determined at frequent intervals in time. However, it is also necessary to disturb the growth process slightly in order to initiate the action of the control mechanism, and having done so, to isolate the effect of the disturbance on growth and thus the action of the control mechanism. This is done by expressing the specific growth rate of organisms whose growth is disturbed as a percentage of that of control organisms of the same age.Experiments in which various toxic agents have been used to disturb growth show that the response of the control mechanism is indiscriminate, and counteracts inhibition irrespective of the agent responsible. The results of further experiments in which colonies were subjected to changes in the level of inhibitor, or in which the inhibitor was removed after the colonies had equilibrated to it, are consistent with the behaviour of a control mechanism operating by negative feedback. Corroborative evidence for this hypothesis comes from work with a simulation model employing feedback. This interpretation of growth control also helps to explain the results of other experiments in which increased resistance to a toxicant resulted from prior exposure to low levels, and others in which ' catch-up' growth and hormesis were observed.

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Section: Experiments With Various Growth Inhibitorsmentioning

confidence: 97%

The kinetics of growth control in a colonial hydroid

Stebbing

1981

J. Mar. Biol. Ass.

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“…Cellular responses are controlled by complex biomolecular signaling pathways whose interactions follow the principles of cybernetic control systems. In addition to the stimulus itself, signal transduction in cells is characterized by four features, (29,30). Two of these are responsible for the recognition and processing of incoming information: the semantics of response, and two are responsible for executing the appropriate response: the pragmatics of response (see Table 4).…”

Section: Programmed Radiation Responsementioning

confidence: 99%

Programmed Cellular Response to Ionizing Radiation Damage

Crompton

1998

Acta Oncologica

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“…In addition to the stimulus itself, signal transduction in cells is characterised by four features (259,260). Two of these are responsible for the recognition and processing of incoming information: the semantics of response.…”

Section: Cybersomes Semantics and Cell Cycle Arrestmentioning

confidence: 99%

“…Signals are a special form of information. As opposed to static, structural information, signals circulate in cybernetic systems (260). Five characteristics of signals are recognised: statistics; symbols and their frequency (262), syntax; signal coding and grammar (263), semantics; the meaning, pragmatics; execution of response, apobetics, (264).…”

Section: Cybersomes Semantics and Cell Cycle Arrestmentioning

confidence: 99%

Programmed Cellular Response in Radiation Oncology: Basic and Translational Studies

Crompton¹

1998

Acta Oncologica

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Fundamentals of Cybernetics

Cited by 19 publications

References 0 publications

The kinetics of growth control in a colonial hydroid

The kinetics of growth control in a colonial hydroid

Programmed Cellular Response to Ionizing Radiation Damage

Programmed Cellular Response in Radiation Oncology: Basic and Translational Studies

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