For the investigation of variable amplitude loading effects, it is necessary to increase the test frequency of conventional testing facilities because, for the evaluation of many components, test results with more than 107 cycles are also needed. However, due to the restriction of conventional testing facilities and the associated costs and required time, variable amplitude testing is almost limited to 107 cycles. Service loading with more than 107 cycles to failure is characterized by low amplitudes with a high number of cycles. The challenge in investigation of material fatigue in the regimes of high cycle and very high cycle fatigue is to apply this large number of cycles to failure in an acceptable time frame. For this reason, it is essential to use a machine, which is able to operate at high frequencies. In this paper, two testing machine concepts with piezo actuators are presented. In the first concept, a high performance piezo stack actuator is presented, in whic h the specimen and the load cell are mechanically assembled in series. This set-up applies forces up to 10 kN and testing frequencies up to 1000 Hz. The second testing facility is a hybrid testing system, which consists of an inertial mass actuator and a servo hydraulic actuator connected in parallel. Both systems are capable of testing normal specimen dimensions and provide the possibility to work with variable amplitude loading as well as constant amplitude loading