Fungaemia due to Fusarium spp. in cancer patients

Krčméry, V.; Jesenská, Zdenka; Špánik, S.; Gyarfás, J; Nogova, J.; Botek, R.; Mardiak, J; Šufliarský, Jozef; Sisolakova, J.; Vanickova, M.; Kunová, A.; Studena, M.; Trupl, J.

doi:10.1016/s0195-6701(97)90197-3

Cited by 54 publications

(34 citation statements)

References 14 publications

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“…Other investigators have found somewhat lower AMB MICs; however, smaller numbers of isolates (2, 7, 18) or different methods (19) were used in these studies. Nevertheless, our findings are in concordance with the accumulated clinical experience of frequent treatment failures in using AMB for invasive fusariosis (4,10,11,15).…”

Section: Disseminated Infection Due To the Emerging Fungal Pathogensupporting

confidence: 91%

“…Its incidence appears to be increasing over the last 15 years (10), and local clusters of disease have been encountered (9). Mortality rates as high as 80% are seen and are in part due to the relative resistance of this genus to present antifungal agents (4,10,11,13,15). Fusarium solani and Fusarium oxysporum are the most frequently described causes of human infection (9,10,13).…”

Section: Disseminated Infection Due To the Emerging Fungal Pathogenmentioning

confidence: 99%

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In Vitro Activities of Investigational Triazoles againstFusariumSpecies: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results

Paphitou

Ostrosky-Zeichner

Paetznick

et al. 2002

Antimicrob Agents Chemother

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Section: Disseminated Infection Due To the Emerging Fungal Pathogensupporting

confidence: 91%

Section: Disseminated Infection Due To the Emerging Fungal Pathogenmentioning

confidence: 99%

In Vitro Activities of Investigational Triazoles againstFusariumSpecies: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results

Paphitou

Ostrosky-Zeichner

Paetznick

et al. 2002

Antimicrob Agents Chemother

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“…They are ubiquitous in soil and decaying plant material, where they act as decomposers, but they are also host-specific pathogens of a number of agriculturally important plants, including pea, cucurbits, and sweet potato. Moreover, they are increasingly associated with opportunistic infections of humans and other animals, causing systemic infections with a high mortality rate (8), as well as localized infections in the skin and other body parts (5,6). In immunocompetent patients, FSSC isolates are mainly known from mycotic keratitis subsequent to traumatic introduction of inoculum.…”

mentioning

confidence: 99%

Members of theFusarium solaniSpecies Complex That Cause Infections in Both Humans and Plants Are Common in the Environment

et al. 2006

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Members of the Fusarium solani species complex (FSSC) are increasingly implicated as the causative agents of human mycoses, particularly in the expanding immunocompromised and immunosuppressed patient populations. Best known as ubiquitous plant pathogens and saprotrophs, the FSSC comprises over 45 phylogenetically distinct species distributed among three major clades. To identify which species are associated with human infections, we generated multilocus haplotypes based on four partial gene sequences from 471 isolates. Of these, 278 were from human patients, 21 were from hospital environments, and 172 were from other sources. Phylogenetic trees inferred from an ergosterol biosynthesis gene (erg-3) were highly discordant with those inferred from the three other partial gene sequences; therefore, this partition was analyzed separately. Multilocus analysis showed that isolates from humans were restricted to but spread throughout clade 3 of the FSSC phylogeny, comprising at least 18 phylogenetically distinct species. The majority (74.5%) of the clinical isolates, however, were associated with four major lineages, designated groups 1 to 4. Groups 1 and 2 were strongly supported as phylogenetic species, whereas groups 3 and 4 were not. Although isolates from ocular infections were found in all four groups, they had a significant tendency to belong to group 3 (P < 0.001). Human clinical isolates shared identical multilocus haplotypes with isolates from plants, other animals, and from hospital environments, suggesting potential nosocomiality. The major finding of this study is that FSSC-associated mycoses of humans and other animals have origins in a broad phylogenetic spectrum, indicating widespread ability to cause infection in this diverse species complex.Fusarium solani is one of the most frequently isolated fungi from soil and plant debris and is also associated with serious invasive mycoses in immunocompromised and immunosuppressed patients (3,18). This species, as defined based on morphology, is actually a diverse complex of over 45 phylogenetic and/or biological species (13 and this study), termed the Fusarium solani species complex (FSSC). These morphologically similar species are generally identified broadly under the name F. solani (12). They are ubiquitous in soil and decaying plant material, where they act as decomposers, but they are also host-specific pathogens of a number of agriculturally important plants, including pea, cucurbits, and sweet potato. Moreover, they are increasingly associated with opportunistic infections of humans and other animals, causing systemic infections with a high mortality rate (8), as well as localized infections in the skin and other body parts (5, 6). In immunocompetent patients, FSSC isolates are mainly known from mycotic keratitis subsequent to traumatic introduction of inoculum. Neutropenic patients, a category of particularly strongly immunocompromised patients, are susceptible to dissemination of infection from superficial or subcutaneous initiation; such infections ar...

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“…In recent years, there have been an increasing number of reports of human infection due to Fusarium species, mostly involving immunocompromised hosts (3,10,16,19). Some consider it the second most common mold pathogen in these patients (8), causing localized infection, deep-seated skin infections, and disseminated disease.…”

mentioning

confidence: 99%

Clinical and Epidemiological Aspects of Infections Caused byFusariumSpecies: a Collaborative Study from Israel

Nir-Paz

Strahilevitz²,

Shapiro

et al. 2004

J Clin Microbiol

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Fusarium infections are an important problem worldwide, commonly affecting immunocompromised individuals. We conducted a retrospective study in two Israeli tertiary medical centers of factors predisposing to infection by Fusarium spp. and their influence on the epidemiology and clinical outcome of this infection. Fusarium spp. were isolated from 89 patients with a median age of 57 years. Sixty-eight patients were considered immunocompetent. Seven patients had disseminated disease, 34 had locally invasive disease, and 48 had superficial infection. Most infections were limited and occurred mainly in lower limbs. Factors associated with in-hospital mortality were chronic renal failure, hematological malignancy, immunosuppression, disseminated infection, and positive blood culture. Multivariate analysis showed that chronic renal failure, hematological malignancy, burns, and disseminated infection were independently associated with mortality. A surge in the frequency of infections was noticed during the summer for patients from rural areas, involving mainly the eyes and lungs. At one of the hospitals (in a mountainous area), there was an increase in the isolation rate over time.

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Fungaemia due to Fusarium spp. in cancer patients

Cited by 54 publications

References 14 publications

In Vitro Activities of Investigational Triazoles againstFusariumSpecies: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results

In Vitro Activities of Investigational Triazoles againstFusariumSpecies: Effects of Inoculum Size and Incubation Time on Broth Microdilution Susceptibility Test Results

Members of theFusarium solaniSpecies Complex That Cause Infections in Both Humans and Plants Are Common in the Environment

Clinical and Epidemiological Aspects of Infections Caused byFusariumSpecies: a Collaborative Study from Israel

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