Fungal fibrosing mediastinitis in pregnancy – Case report with review of literature

Vaideeswar, Pradeep; Chaudhari, Jayashri; Goel, Naina

doi:10.4103/jpgm.jpgm_358_18

Cited by 7 publications

(2 citation statements)

References 14 publications

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“…It can either be a response to various infective (histoplasmosis, tuberculosis, and aspergillosis) or noninfective (IgG4 related) causes or may be idiopathic. [ 9 ] The disease can affect any age group with equal predilection for both genders. However, in the case of IgG4-related fibrosing mediastinitis, associated with an elevated IgG4 levels in the blood and tissue, the median age of affected patients reported is 56 years with a distinct male preponderance (11:4).…”

Section: Salient Features Of the Case And Differential Diagnosismentioning

confidence: 99%

A young immunocompetent female with anterior mediastinal mass

2021

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Section: Salient Features Of the Case And Differential Diagnosismentioning

confidence: 99%

A young immunocompetent female with anterior mediastinal mass

2021

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“…However, the same exposure can result in serious pathogenic effects in individuals with certain underlying diseases such as cancer or immune deficiency disorders. Until recently, the major known direct pathogenic effects of Aspergillus species have included allergies, toxicities, and a variety of infections [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ,…”

Section: Introductionmentioning

confidence: 99%

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Tebbi¹

2023

JoF

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Certain viruses have been found to induce diverse biological pathways to carcinogenesis, evidenced by the presence of viral gene products in some tumors. Despite the fact that many fungal agents contain mycoviruses, until recently, their possible direct effects on human health, including carcinogenesis and leukemogenesis, had not been explored. In this regard, most studies of fungal agents have rightly concentrated on their mycotoxin formation and effects. Recently, the direct role of yeasts and fungi in the etiology of cancers, including leukemia, have been investigated. While greater attention has been placed on the carcinogenic effects of Candida, the role of filamentous fungi in carcinogenesis has also been explored. Recent findings from studies using the enzyme-linked immunosorbent assay (ELISA) technique indicate that the plasma of patients with acute lymphoblastic leukemia (ALL) uniformly contains antibodies for a certain mycovirus-containing Aspergillus flavus, while controls are negative. The exposure of mononuclear leukocytes from patients with ALL in full remission, and long-term survivors, to the product of this organism was reported to result in the re-development of typical genetics and cell surface phenotypes characteristic of active ALL. Mycoviruses are known to be able to significantly alter the biological characteristics and functions of their host. The possible carcinogenic and leukemogenic role of mycoviruses, with and without their host, needs to be further investigated.

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Placental and breastmilk transfer of voriconazole to offspring from pregnant and lactating bottlenose dolphins (Tursiops truncatus)

Ohno¹,

Kobayashi²,

Akune³

et al. 2019

Medical Mycology

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Fungal pneumonia is a common disease in bottlenose dolphins (Tursiops truncatus), including pregnant and lactating ones. Voriconazole (VRCZ) is commonly used to treat respiratory fungal infections in this species; however, it is unknown whether VRCZ is transferred via the placenta and breastmilk and whether its usage is safe in pregnant and lactating dolphins. We measured VRCZ concentrations in breastmilk and dams’, umbilical cord, and calves’ plasma samples from four dam-calf dolphin pairs in the Port of Nagoya Public Aquarium, Japan, treated with or without VRCZ. Three pregnant and/or lactating dams were administered VRCZ (loading dose 1.5–2.3 mg/kg, for 3 days; maintenance dose 1.5–3.1 mg/kg, every 5–18 days), twice daily, orally, without side effects in dams or calves. VRCZ was detected in two dams’ umbilical cord plasma (0.14 and 2.35 μg/ml) and in one calf's plasma (0.18 μg/ml), collected immediately after birth. Further, VRCZ was detected in breastmilk samples (maximum 13.45 μg/ml) from three VRCZ-administered dams and in plasma from three calves (maximum 7.54 μg/ml) given or nursed from VRCZ-administered dams’ breastmilk. The calves’ plasma VRCZ concentrations varied, depending on the amount of breastmilk and food consumed. VRCZ concentrations were higher in breastmilk samples than in dams’ plasma. To our knowledge, this is the first report on placental and breastmilk VRCZ transfer to offspring in bottlenose dolphins. During VRCZ medication in pregnant and lactating bottlenose dolphins, it is crucial to monitor plasma VRCZ concentrations and any side effects in dams as well as in their calves.

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Fungal fibrosing mediastinitis in pregnancy – Case report with review of literature

Cited by 7 publications

References 14 publications

A young immunocompetent female with anterior mediastinal mass

A young immunocompetent female with anterior mediastinal mass

Mycoviruses in Fungi: Carcinogenesis of Fungal Agents May Not Always Be Mycotoxin Related

Placental and breastmilk transfer of voriconazole to offspring from pregnant and lactating bottlenose dolphins (Tursiops truncatus)

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