2022
DOI: 10.3389/fmicb.2022.888452
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Fungal Infection in Co-infected Patients With COVID-19: An Overview of Case Reports/Case Series and Systematic Review

Abstract: Fungal co-infections are frequent in patients with coronavirus disease 2019 (COVID-19) and can affect patient outcomes and hamper therapeutic efforts. Nonetheless, few studies have investigated fungal co-infections in this population. This study was performed to assess the rate of fungal co-infection in patients with COVID-19 as a systematic review. EMBASE, MEDLINE, and Web of Science were searched considering broad-based search criteria associated with COVID-19 and fungal co-infection. We included case report… Show more

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Cited by 35 publications
(27 citation statements)
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“…Critically ill patients, those with ARDS, and patients on corticosteroids are more likely to develop CAPA 11–13 . It is necessary to mention that, hypertension and diabetes mellitus are the most common comorbidities in patients with secondary fungal infections in the context of COVID‐19, which was also the case with our patient 14–16 . Considerably, this past medical history has definitely played a role in both episodes of fungal infections.…”
Section: Discussionsupporting
confidence: 55%
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“…Critically ill patients, those with ARDS, and patients on corticosteroids are more likely to develop CAPA 11–13 . It is necessary to mention that, hypertension and diabetes mellitus are the most common comorbidities in patients with secondary fungal infections in the context of COVID‐19, which was also the case with our patient 14–16 . Considerably, this past medical history has definitely played a role in both episodes of fungal infections.…”
Section: Discussionsupporting
confidence: 55%
“…[11][12][13] It is necessary to mention that, hypertension and diabetes mellitus are the most common comorbidities in patients with secondary fungal infections in the context of COVID-19, which was also the case with our patient. [14][15][16] Considerably, this past medical history has definitely played a role in both episodes of fungal infections. CAPA should be proven by histopathological studies or direct microscopic detection or both.…”
Section: Discussionmentioning
confidence: 99%
“…Secondary infections in COVID-19 that result in fulminant neurological morbidity are most commonly due to fungal pathogens, including Mucor spp., Rhizopus spp., and Aspergillus spp. 46 The high prevalence of obesity and diabetes mellitus, impaired cell-mediated immunity during infection, and increased use of corticosteroids to treat COVID-19 are thought to be some of the factors causing an increased incidence of rhino-orbito-cerebral mucormycosis. [46][47][48] While over 20,000 COVID-19-related cases of mucormycosis were identified in India alone, few brain autopsies have been reported in patients with COVID-19.…”
Section: Secondary Infectionsmentioning
confidence: 99%
“…46 The high prevalence of obesity and diabetes mellitus, impaired cell-mediated immunity during infection, and increased use of corticosteroids to treat COVID-19 are thought to be some of the factors causing an increased incidence of rhino-orbito-cerebral mucormycosis. [46][47][48] While over 20,000 COVID-19-related cases of mucormycosis were identified in India alone, few brain autopsies have been reported in patients with COVID-19. 46,[48][49][50][51][52][53] Brain edema, extensive necrosis, and angioinvasive fungal organisms with wide, pauciseptate, irregularly branched hyphae can be identified within cerebral mass lesions (►Fig.…”
Section: Secondary Infectionsmentioning
confidence: 99%
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