Fungal Infections Caused by <i>Kazachstania</i> spp., Strasbourg, France, 2007–2020

Kaeuffer, Charlotte; Baldacini, Mathieu; Ruge, Tiffany; Ruch, Yvon; Zhu, Yves-Jean; Cian, Manon De; Philouze, Guillaume; Bachellier, Philippe; Denis, Julie; Lefèbvre, Nicolas; Schneider, Francis; Hansmann, Yves; Letscher-Bru, Valérie; Herbrecht, Raoul; Sabou, Marcela; Danion, François

doi:10.3201/eid2801.211543

Cited by 11 publications

(11 citation statements)

References 12 publications

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“…K. telluris is an opportunistic yeast that can cause fungemia in humans. This particular yeast is frequently confected with C. albicans [ 39 ]. In the present study, we found K. telluris colonized in the pigeon excreta at a rate of approximately 4.77%.…”

Section: Discussionmentioning

confidence: 99%

Identification of Pathogenic and Opportunistic Yeasts in Pigeon Excreta by MALDI-TOF Mass Spectrometry and Their Prevalence in Chon Buri Province, Thailand

Nualmalang

Thanomsridetchai

Teethaisong

et al. 2023

IJERPH

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Pigeon excreta can cause environmental and public health issues, particularly in urban and public areas. They are reservoirs of several human pathogens including fungi, bacteria, and viruses. Epidemiological data of pathogenic and opportunistic yeasts in pigeon droppings in Chon Buri, one of the most reputable tourist cities of Thailand, are scarce. The present study aimed to identify yeasts in pigeon droppings by MALDI-TOF mass spectrometry, and to study their prevalence in Chon Buri, Thailand. A total of 200 pigeon fecal samples were collected randomly from all 11 districts of Chon Buri. A sum of 393 yeast-like colonies were isolated on Sabourand’s dextrose agar and CHROMagar media. These isolates were further confirmed for their species by MALDI-TOF MS. Twenty-four yeast species belonging to 11 different genera were identified in pigeon fecal samples. Candida spp., predominantly C. krusei (14.32%), were the most prevalent yeast species. Other yeast species, including C. glabrata (12.73%), C. metapsilosis (11.93%), Lodderomyces elongisporus (10.87%), C. tropicalis (7.16%), C. albicans (5.83%), and Cryptococcus neoformans (4.77%) were identified. This study provides valuable epidemiological data and diversity of yeasts in pigeon droppings in Chon Buri, Thailand, and also supports the use of MALDI-TOF MS for yeast identification and epidemiological surveillance.

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Section: Discussionmentioning

confidence: 99%

Identification of Pathogenic and Opportunistic Yeasts in Pigeon Excreta by MALDI-TOF Mass Spectrometry and Their Prevalence in Chon Buri Province, Thailand

Nualmalang

Thanomsridetchai

Teethaisong

et al. 2023

IJERPH

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“…Albeit rare, Syphacia sp. can infect humans and is a zoonotic parasite [ 69 , 70 ]. Heligmosomoides sp.…”

Section: Discussionmentioning

confidence: 99%

Metabarcoding of bacteria and parasites in the gut of Apodemus agrarius

Kim

Choi

et al. 2022

Parasites Vectors

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Background The striped field mouse Apodemus agrarius is a wild rodent commonly found in fields in Korea. It is a known carrier of various pathogens. Amplicon-based next-generation sequencing (NGS) targeting the 16S ribosomal RNA (rRNA) gene is the most common technique used to analyze the bacterial microbiome. Although many bacterial microbiome analyses have been attempted using feces of wild animals, only a few studies have used NGS to screen for parasites. This study aimed to rapidly detect bacterial, fungal and parasitic pathogens in the guts of A. agrarius using NGS-based metabarcoding analysis. Methods We conducted 18S/16S rDNA-targeted high-throughput sequencing on cecal samples collected from A. agrarius (n = 48) trapped in May and October 2017. Taxa of protozoa, fungi, helminths and bacteria in the cecal content were then identified. Results Among the protozoa identified, the most prevalent was Tritrichomonas sp., found in all of the cecal samples, followed by Monocercomonas sp. (95.8% prevalence; in 46/48 samples) and Giardia sp. (75% prevalence; in 36/48 samples). For helminths, Heligmosomoides sp. was the most common, found in 85.4% (41/48) of samples, followed by Hymenolepis sp. (10.4%; 5/48) and Syphacia sp. (25%; 12/48). The 16S rRNA gene analysis showed that the microbial composition of the cecal samples changed by season (P = 0.005), with the linear discriminant analysis effect size showing that in the spring Escherichia coli and Lactobacillus murinus were more abundant and Helicobacter rodentium was less abundant. Helicobacter japonicus was more abundant and Prevotella_uc was less abundant in males. The microbial composition changed based on the Heligmosomoides sp. infection status (P = 0.019); specifically, Lactobacillus gasseri and Lactobacillus intestinalis were more abundant in the Heligmosomoides sp.-positive group than in the Heligmosomoides sp.-negative group. Conclusions This study demonstrated that bacterial abundance changed based on the season and specific parasitic infection status of the trapped mice. These results highlight the advantages of NGS technology in monitoring zoonotic disease reservoirs. Graphical Abstract

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“…A single-center French study identified 13 cases of Kazachstania spp. infection expanding over 14 years, three of which qualified for invasive disease [ 75 ]. Two other cases of invasive disease had been reported earlier.…”

Section: Introductionmentioning

confidence: 99%

“…Two other cases of invasive disease had been reported earlier. The infection has been observed in immunocompromised individuals, and identification of the fungi is performed using MALDI-TOF and ITS sequencing [ 75 ].…”

Section: Introductionmentioning

confidence: 99%

Candidiasis and Other Emerging Yeasts

Sharma

Chakrabarti²

2023

Curr Fungal Infect Rep

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Purpose of Review The review presents a comprehensive and updated information on the contemporary status of invasive candidiasis (IC), other emerging yeast infections, and the challenges they present in terms of at-risk population, specific virulence attributes, and antifungal susceptibility profile. Recent Findings With the advancement in medical field, there has been parallel expansion of vulnerable populations over the past two decades. This had led to the emergence of a variety of rare yeasts in healthcare settings, both Candida and non-Candida yeast causing sporadic cases and outbreaks. The advancements in diagnostic modalities have enabled accurate identification of rare Candida species and non-Candida yeast (NCY) of clinical importance. Their distribution and susceptibility profile vary across different geographical regions, thus necessitating surveillance of local epidemiology of these infections to improve patient outcomes. Summary The challenges in management of IC have been complicated with emergence of newer species and resistance traits. C. tropicalis has already overtaken C. albicans in many Asian ICUs, while C. auris is rising rapidly worldwide. Recent genomic research has reclassified several yeasts into newer genera, and an updated version of MALDI-TOF MS or ITS sequencing is necessary for accurate identification. Having a knowledge of the differences in predisposing factors, epidemiology and susceptibility profile of already established pathogenic yeasts, as well as new emerging yeasts, are imperative for better patient management.

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Fungal Infections Caused by Kazachstania spp., Strasbourg, France, 2007–2020

Abstract: Emergence might be associated with increasing immunocompromised conditions and gastroesophageal diseases.

Cited by 11 publications

References 12 publications

Identification of Pathogenic and Opportunistic Yeasts in Pigeon Excreta by MALDI-TOF Mass Spectrometry and Their Prevalence in Chon Buri Province, Thailand

Identification of Pathogenic and Opportunistic Yeasts in Pigeon Excreta by MALDI-TOF Mass Spectrometry and Their Prevalence in Chon Buri Province, Thailand

Metabarcoding of bacteria and parasites in the gut of Apodemus agrarius

Candidiasis and Other Emerging Yeasts

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