Fungal Infections of the CNS

Blatzer, Michael; Latgé, Jean‐Paul; Beauvais, Anne; Bretagne, Stéphane; Chrétien, Fabrice; Jouvion, Grégory

doi:10.1002/9781119467748.ch44

Infections of the Central Nervous System 2020

DOI: 10.1002/9781119467748.ch44

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Fungal Infections of the CNS

Michael Blatzer

Jean‐Paul Latgé

Anne Beauvais

et al.

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2023

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Synthesis of 1,3,4-Oxadiazoles with 4-Methoxynaphthalene Ring: Discovering New Compounds with Antimicrobial Activity

Frederico Rozada,

Vilugron Rodrigues-Vendramini,

Kioshima

et al. 2023

Future Med. Chem.

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Background: Paracoccidioidomycosis (PCM) is a systemic infection caused by Paracoccidioides spp. ( Pb). PCM can be associated or clinically confused with tuberculosis (TB), another pulmonary infection, caused by Mycobacterium tuberculosis ( Mtb). Futhermore, the long treatment time of TB and PCM and the cases of TB drug resistance impose difficulties for the cure of these diseases. Results: New 1,3,4-oxadiazoles containing the 4-methoxynaphthalene ring were synthesized and their antimicrobial activity was evaluated against Pb and Mtb. The derivative 6n (with 2-hydroxy-5-nitrophenyl subunit) is the most promising of the series. Conclusion: The 1,3,4-oxadiazole 6n can be used as a prototype drug candidate, with anti- Pb and anti- MTb activities, showing a broad-spectrum profile for the treatment of both pulmonary infections.

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Synthesis of 1,3,4-Oxadiazoles with 4-Methoxynaphthalene Ring: Discovering New Compounds with Antimicrobial Activity

Frederico Rozada,

Vilugron Rodrigues-Vendramini,

Kioshima

et al. 2023

Future Med. Chem.

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show abstract

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Fungal Infections of the CNS

Cited by 1 publication

References 57 publications

Synthesis of 1,3,4-Oxadiazoles with 4-Methoxynaphthalene Ring: Discovering New Compounds with Antimicrobial Activity

Synthesis of 1,3,4-Oxadiazoles with 4-Methoxynaphthalene Ring: Discovering New Compounds with Antimicrobial Activity

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