Fungal keratitis following amniotic membrane transplantation

Das, Sujata; Sangwan, Veena

doi:10.1007/s10792-007-9164-4

Cited by 11 publications

(4 citation statements)

References 7 publications

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“…The use of PROKERA facilitates early and easy intervention with comparable efficacy [ 2 ]. However, cases of early and late (after 30 days)-onset postoperative microbial infections can occur (Table 1 ) [ 6 , 7 , 8 ].…”

Section: Discussion/conclusionmentioning

confidence: 99%

Microbial Keratitis following Self-Retained Cryopreserved Amniotic Membrane

Fairaq

Albalawi

Al-Swailem

2022

Case Rep Ophthalmol

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The aim of this study was to report a severe case of mixed fungal and bacterial microbial keratitis following implantation of a self-retained cryopreserved amniotic membrane, PROKERA® SLIM (Bio-Tissue, Inc) in a patient with history of neurotrophic ulcer secondary to herpetic epithelial keratitis. Despite maximally tolerated topical and systemic therapy, the patient’s eye continued to deteriorate and eventually required evisceration. PROKERA implantation might be associated with severe recalcitrant microbial keratitis. Caution is urged when considering implantation especially in monocular patients.

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Section: Discussion/conclusionmentioning

confidence: 99%

Microbial Keratitis following Self-Retained Cryopreserved Amniotic Membrane

Fairaq

Albalawi

Al-Swailem

2022

Case Rep Ophthalmol

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“… 6 Das et al reported Aspergillus species isolated from the cornea, four weeks after AMT. 7 In this case report, our patient received tissue that had been prepared under good tissue banking practices by a technician certified by the Eye Bank Association of America at the King Khaled Eye Specialist Hospital Eye Bank.…”

Section: Discussionmentioning

confidence: 99%

Late-onset granular intra-amniotic infection following amniotic membrane transplantation

Alreshidi

Al-Swailem

2021

American Journal of Ophthalmology Case Reports

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Background The amniotic membrane (AM) is used in ocular surface reconstruction and is effective at promoting epithelialization and preventing corneal perforation in cases of acute microbial keratitis. Here, we report a case of isolated AM infection after AM transplantation for a persistent epithelial defect following tectonic penetrating keratoplasty. Case presentation A 47-year-old man with poorly controlled type 2 diabetes mellitus presented to the emergency department with a referral for perforated microbial keratitis. After ophthalmic examination, corneal scraping was performed, and corneal gluing was attempted and failed. Hence, the patient underwent tectonic penetrating keratoplasty. After keratoplasty, the patient developed a persistent epithelial defect that required AM transplantation as an overlay. Thirty days post-AM transplant, the patient presented with signs and symptoms resembling granular microbial infection of the cornea. After two days, the granular findings began dislodging from the corneal surface and were sent for culture, sensitivity, and histopathological identification. Histological analysis of the granular material indicated it to be a small piece of AM stroma infiltrated with mixed-type inflammatory cells. Corneal scraping cultures indicated Streptococcus mitis and Streptococcus oralis . Conclusion The infiltrate was localized to the basement membrane of the AM as, despite the anti-inflammatory effects of AM, it can also act as a barrier against polymorphonuclear leukocyte infiltration from the tear film and microbial invasion into the cornea.

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“…21 Organisms responsible include Grampositive pathogens 22 and Aspergillus sp. 23 Complications that have been reported after PTK for bullous keratopathy include delayed epithelial healing, microbial keratitis, and the need for retreatment. 5 None of the eyes in the PTK group in our series developed any complication after the procedure.…”

Section: Discussionmentioning

confidence: 99%