Fungal mediated kinetic resolution of racemic acetates to ( R )-alcohols using Fusarium proliferatum

Jadhav, Dipesh D.; Patil, Harshal S.; Chaya, Patil S.; Thulasiram, Hirekodathakallu V.

doi:10.1016/j.tetlet.2016.08.084

Cited by 3 publications

(2 citation statements)

References 33 publications

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“…Fusarium proliferatum NCIM1105 used for hydrolytic kinetic resolution of racemic 1 afforded 100% enantiomerically pure (R)-2 within 36 h [33]. In the present study, comparable results were obtained with A. nidulans AM243, P. camemberti AM83, and F. avenaceum AM11 (Tables 1 and 2).…”

Section: Kinetic Resolution Of 1-phenylethyl Acetate (1)supporting

confidence: 83%

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Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

et al. 2018

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A novel microbial approach to the production of enantiomerically enriched and pure aroma compounds based on kinetic resolution via solid-state fermentation is proposed. Twenty-five filamentous fungi were screened for lipase activity and enantioselective hydrolysis of a volatile racemic ester (1-phenylethyl acetate (1)) and several racemic lactones (trans and cis whisky lactones (4, 5), γ-decalactone (7), δ-decalactone (8), (cis-3a,4,7,7a-tetrahydro-1(3H)-isobenzofuranone) (9)). Solid-state fermentation was conducted with linseed and rapeseed cakes. Kinetic resolution afforded enantiomerically enriched products with high enantiomeric excesses (ee = 82-99%). The results highlight the potential economic value of solid-state fermentation using agroindustrial side-stream feedstocks as an alternative to more expensive processes conducted in submerged fermentation.

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Section: Kinetic Resolution Of 1-phenylethyl Acetate (1)supporting

confidence: 83%

“…A few examples of fungal kinetic resolution, although in submerged fermentation, of ester 1 can be found in recent literature [32,33]. Fusarium proliferatum NCIM1105 used for hydrolytic kinetic resolution of racemic 1 afforded 100% enantiomerically pure (R)-2 within 36 h [33].…”

Section: Kinetic Resolution Of 1-phenylethyl Acetate (1)mentioning

confidence: 99%

Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

et al. 2018

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Fusarium: Biodiversity, Ecological Significances, and Industrial Applications

Abdel-Azeem

Darwish

et al. 2019

Fungal Biology

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Fusarium species—a promising tool box for industrial biotechnology

Pessôa

Paulino

Mano

et al. 2017

Appl Microbiol Biotechnol

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Global demand for biotechnological products has increased steadily over the years. Thus, need for optimized processes and reduced costs appear as a key factor in the success of this market. A process tool of high importance is the direct or indirect use of enzymes to catalyze the generation of various substances. Also, obtaining aromas and pigments from natural sources has becoming priority in cosmetic and food industries in order to supply the demand from consumers to substitute synthetic compounds, especially when by-products can be used as starting material for this purpose. Species from Fusarium genera are recognized as promising sources of several enzymes for industrial application as well as biocatalysts in the production of aromas, pigments and second generation biofuels, among others. In addition, secondary metabolites from these strains can present important biological activities for medical field. In this approach, this review brings focus on the use of Fusarium sp. strains in biotechnological production of compounds of industrial interest, showing the most recent researches in this area, results obtained and the best process conditions for each case.

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Fungal mediated kinetic resolution of racemic acetates to ( R )-alcohols using Fusarium proliferatum

Cited by 3 publications

References 33 publications

Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

Microbial Kinetic Resolution of Aroma Compounds Using Solid-State Fermentation

Fusarium: Biodiversity, Ecological Significances, and Industrial Applications

Fusarium species—a promising tool box for industrial biotechnology

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