Furanocoumarins in Celery and Parsnips: Method and Multiyear Canadian Survey

Abstract

The natural occurrence of biologically active furanocoumarins in common vegetables is an area of increasing interest with respect to human health. In this study, an efficient, rugged, and sensitive liquid chromatographic method with ultraviolet photodiode array detection was developed for the estimation of 5 biologically active furanocoumarins (psoralen, bergapten, xanthotoxin, trioxsalen, and angelicin) in celery and parsnips. When authentic samples were spiked with a mixture of furanocoumarins at individual levels of 2 to 10 μg/g, the method produced overall recoveries of 77 and 75%of all furanocoumarins from celery and parsnips, respectively. The method was applied in 2 laboratories to a multiyear survey of more than 200 samples. Of 110 parsnips samples, 109 (99%) contained quantitatable levels of furanocoumarins. The mean level of total furanocoumarins in the positive parsnip samples was 15.1 μg/g; the maximum level detected was 145 μg/g. Of 114 celery samples, 88 (77%) contained quantitatable levels of furanocoumarins. The mean level of total furanocoumarins in the positive celery samples was 1.9 μg/g; the maximum level detected was 15.2 μg/g. Xanthotoxin and bergapten were the most commonly detected furanocoumarins in both celery (68 and 63%) and parsnips (97 and 96%). Xanthotoxin had the highest mean level of positives in both celery (1.3 μg/g) and parsnips (8.5 μg/g). Little year-to-year variation in either total furanocoumarin levels or incidence was noted.

Antioxidant Activities of Celery and Parsley Juices in Rats Treated with Doxorubicin

“…Linnaeus classified it Apium petroselinum L.) contains flavonoids (apiin and luteolin) and essential oil (apiol and myristicin), responsible for both the medical uses and toxicity of parsley. Furanocoumarins (psoralen, bergapten, isoimperatorin, oxypeucedanin, xanthoxin, trioxalen and angelicin) are other important chemical constituents of parsley plants [ 6 , 7 ].…”

dbEST‐derived microsatellite markers in celery (Apium graveolens L. var. dulce)

“…Nowadays its cultivation spreads all over the world. Celery is mainly grown for the production of fleshy stems consumed as fresh vegetable or spice, but it is also used for the extraction of terpenes, furano‐coumarins (Lombaert et al . 2001; Ludwiczuk et al .…”

Amotosalen interactions with platelet and plasma components: absence of neoantigen formation after photochemical treatment

“…The 35 patients enrolled in this study had a substantial exposure (40-60 mL/kg/day for up to 35 days per cycle) to either PCT or reference plasma, with daily total plasma volume exchanges as the mainstay of their therapy. Seventeen patients received test plasma in Cycle 1, and 3 of these patients had an additional exposure to test plasma in Cycle 2 with a mean of 11.3 (range, 6-30) plasma exchanges in Cycle 1 and 15.3 (range, [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]…”

“…[4][5][6] Humans are exposed to 1 to 2 mg per day of naturally occurring psoralens through dietary intake of fruits and vegetables such as limes, parsnips, celery, and parsley. [7][8][9] Amotosalen is a synthetic psoralen, specifically designed for use in blood components. 3 It readily crosses cell membranes, cell walls, and viral membranes and intercalates into DNA and RNA of pathogens as well as WBCs.…”