Furanoeremophilanes and a bakkenolide from Senecio auricula var. major

Torres, Pascual; Ayala, Juan H.; Grande, C.; Macías, María Jesús; Grande, M.

doi:10.1016/s0031-9422(97)00497-4

Cited by 29 publications

(27 citation statements)

References 18 publications

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“…2). The correlations between Hβ-6 and Me-15, Hα-6 and H-13, and H-9 and H-13 indicated that the configuration of C-7 was R [18]. Compound 1 was optically active and in the form of white needles.…”

Section: Supporting Informationmentioning

confidence: 95%

Bakkenolides fromPetasites tricholobusand Their Neuroprotective Effects Related to Antioxidant Activities

Wang¹,

Li²,

Guo³

et al. 2008

Planta Med

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Four novel bakkenolides - bakkenolide-Ia ( 1), bakkenolide-IIa ( 2), bakkenolide-IIIa ( 3) and bakkenolide-IVa ( 4) - were isolated from the extract of the rhizome of Petasites tricholobus. The structures were characterized by using NMR ( (1)H, (13)C, (1)H- (1)H COSY, HMQC, HMBC, and NOESY) and mass spectrometry. The neuroprotective activity of the compounds 1 - 4 was assayed with primary cultured neurons exposed to oxygen-glucose deprivation and oxidative insults. Antioxidant activity of the bakkenolides was evaluated by cell-free bioassays. The IN VITRO assay results showed that all these compounds exhibited significant neuroprotective and antioxidant activities. To our knowledge, this is the first report on the neuroprotective and antioxidant activities of bakkenolides.

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Section: Supporting Informationmentioning

confidence: 95%

Bakkenolides fromPetasites tricholobusand Their Neuroprotective Effects Related to Antioxidant Activities

Wang¹,

Li²,

Guo³

et al. 2008

Planta Med

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“…The roots of S. auricula var. major yielded the three new eremophilane derivatives 149 -151 [66]. The aerial parts of S. flavus contained the four new furanoeremophilanes 158, 159, 161, and 162, oxidized at C(3), and a new eremophilenone lactam, 245.…”

Section: Pyrrolizidine Alkaloidsmentioning

confidence: 99%

Chemical and Pharmacological Research on Plants from the Genus Senecio

Yang

Zhao

Wang

et al. 2011

Chemistry & Biodiversity

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“…Distribution of this species is wider, from Yemen southwards into NE Africa and southwards to South Africa . The genus Senecio is recognized as a source of the saturated and hepatocarcinogenic unsaturated pyrrolizidine alkaloids (PAs) and sesquiterpenoids with furanoeremophilane skeleton . Senecio species leafs are used as a folk medicine in Saudi Arabia for their antipyretic properties .…”

Section: Introductionmentioning

confidence: 99%

Two New Sesquiterpene Alcohols Isolated from Senecio hadiensis Forssk. Grown in Saudi Arabia

Ahmed

Ahmad

Yousaf

et al. 2017

Chemistry & Biodiversity

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Phytochemical investigation on the aerial parts of Senecio hadiensis Forssk. led to the isolation of two new sesquiterpenoids, presilphiperfolan-2α,5α,8α-triol (1) and presilphiperfolan-2α,5α,8α,10α-tetraol (2) featuring the rare presilphiperfolane-type frameworks. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic (1D- and 2D-NMR, HR-ESI-MS) methods and by comparison with the literature data. The isolates 1 and 2 were evaluated in-vitro for antiinflammatory, cytotoxic, and peroxisome proliferator activated receptor alpha and gamma (PPARα and PPARγ) agonistic activities.

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Furanoeremophilanes and a bakkenolide from Senecio auricula var. major

Cited by 29 publications

References 18 publications

Bakkenolides fromPetasites tricholobusand Their Neuroprotective Effects Related to Antioxidant Activities

Bakkenolides fromPetasites tricholobusand Their Neuroprotective Effects Related to Antioxidant Activities

Chemical and Pharmacological Research on Plants from the Genus Senecio

Two New Sesquiterpene Alcohols Isolated from Senecio hadiensis Forssk. Grown in Saudi Arabia

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