Furans and their Benzo Derivatives: Reactivity

The construction of phosphonate triazolyl by copper(ii)-catalyzed furan dearomatized [3 + 2] cycloaddition

“…Biomass-derived furan is used as a prominent structural scaffold in many biologically active molecules due to its low aromaticity, and it is an important adaptable tool in synthetic chemistry with many related transformations documented. [20][21][22] It is not only can serve as masked olefins, enol ethers, 23 1,4-diketones, 24 and carboxylic acids, 25 but it can also be easily recyclized into various carbo- [26][27][28][29][30][31][32][33][34] and heterocyclic rings. [35][36][37][38] In some cases, during the process of producing new scaffolds through furan recyclization, olefins conjugated with carbonyl groups are present in the form of a mixture of Z/E isomers, and the E-isomer is usually the more preferable one.…”

Iodine-Catalyzed Synthesis of Substituted Furans and Pyrans: Reaction Scope and Mechanistic Insights

“…Pyrans and furans are important structural elements of many natural products and pharmaceuticals and valuable reaction precursors or intermediates in organic synthesis . There are several synthetic strategies which yield pyrans and furans bearing different substitution patterns. ,, One frequently used method involves cyclization or cycloaddition reactions of unsaturated carbonyl compounds using transition metal catalysts such as Hg, Au, Pd, Ag, Co, Zn, Cu, Rd, and Pt and other metals such as Ca, Ga, Sc, and Bi …”

Diastereodivergent organocatalysis for the asymmetric synthesis of chiral annulated furans

“…This research project was motivated by our interest in devising a direct and versatile strategy for stereoselectively assembling chiral annulated furans. 1 As shown in Fig. 1 , many biologically active compounds and natural products possess a furan system fused to rings of various sizes and adorned with multiple stereocenters.…”