The construction of phosphonate triazolyl by copper(ii)-catalyzed furan dearomatized [3 + 2] cycloaddition

Abstract

Triazole phosphonates are valuable structural motifs in chemical biology and the subject of growing recent interest. A novel synthetic methodology of triazolyl phosphonates starting from furfuryl phosphonate alcohols and organo...

Advances in Polybenzocoumarins: Synthesis, Applications and Fluorescent Properties

“…Controlling blood pressure and improving vascular function can reduce the side effects of liver damage induced by toxins while maintaining cardiovascular health. [35][36][37] They provide an interesting research object for cancer because they play roles in various biological courses, including cell proliferation, apoptosis, and signaling pathways. The innate antiviral activity of polybenzocoumarins is through interference with viral entry, replication, and enzyme function.…”

“…Some coumarin derivatives have also been studied for their possible hepatoprotective and cardioprotective effects. Controlling blood pressure and improving vascular function can reduce the side effects of liver damage induced by toxins while maintaining cardiovascular health [35–37] …”

Furan ring opening reaction for the synthesis of 2,5-dicarbonyl-3-ene-phosphates

“…21 Building upon our continuous dedication to furan-based transformations, our research endeavors aim to further explore and expand the applications of this versatile class of reactions. 21–27 In this context, herein, we report FeCl 3 catalyzed furan ring opening reaction for the synthesis of 2,5-dicarbonyl-3-ene-phosphates. This method demonstrates a broad substrate scope and offers a high yield, providing a mild and direct route to diverse 2,5-dicarbonyl phosphonates derived from furfuryl phosphonates (Scheme 1b).…”

Furan Dearomatization: A Route to Diverse Fluoroalkyl/Aryl Triazoles

“…Furthermore, it can easily undergo recyclization reactions to produce different carbon rings − or heterocycles . In view of these unique properties of furans, our group developed a method for directly synthesizing complementary triazoles from readily available furan derivatives . This method involves [3 + 2] cycloaddition/furan ring-opening reactions between furfurylcarbinol derivatives and organic azide molecules, thereby synthesizing a series of functionalized 1,2,3-triazole compounds, such as enamide triazoles, 3-chloropropyl substituted enone triazoles, sulfur ester triazoles, phosphate ester triazoles, and so on.…”