Furious lung abscess due to <i>Parvimonas micra</i>

Fukushima, Shinnosuke; Hagiya, Hideharu; Naito, Hiromichi; Otsuka, Fumio

doi:10.1002/rcr2.1161

Cited by 1 publication

(2 citation statements)

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“…P. micra is one of the most prevalent anaerobic microorganisms in the human oral cavity ( Badri et al., 2019 ). However, due to challenges in laboratory culture, there are limited published data on the clinical characteristics of P. micra lung abscess, mainly in the last 5 years ( Yun et al., 2019 ; Yang and Su, 2021 ; Zhang et al., 2021 ; Fukushima et al., 2023 ; Zhijun et al., 2023 ).…”

Section: Discussionmentioning

confidence: 99%

“…P. micra is susceptible to many antibiotics, including penicillin G, ampicillin, cefepime, vancomycin, and metronidazole ( Boattini et al., 2018 ; Fukushima et al., 2023 ). In the case of lung abscess, intravenous antibiotics were administered for 2 to 4 weeks, followed by oral antibiotic treatment for 2 to 3 months until the chest radiographic lesions resolved.…”

Section: Discussionmentioning

confidence: 99%

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Target next-generation sequencing for the accurate diagnosis of Parvimonas micra lung abscess: a case series and literature review

Zhang,

Fan,

Yang

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundParvimonas micra (P. micra) has been identified as a pathogen capable of causing lung abscesses; however, its identification poses challenges due to the specialized culture conditions for anaerobic bacterial isolation. Only a few cases of lung abscesses caused by P. micra infection have been reported. Therefore, we describe the clinical characteristics of lung abscesses due to P. micra based on our case series.MethodsA retrospective analysis was conducted on eight patients who were diagnosed with lung abscesses attributed to P. micra. Detection of P. micra was accomplished through target next-generation sequencing (tNGS). A systematic search of the PubMed database using keywords “lung abscess” and “Parvimonas micra/Peptostreptococcus micros” was performed to review published literature pertaining to similar cases.ResultsAmong the eight patients reviewed, all exhibited poor oral hygiene, with four presenting with comorbid diabetes. Chest computed tomography (CT) showed high-density mass shadows with necrosis and small cavities in the middle. Bronchoscopic examination revealed purulent sputum and bronchial mucosal inflammation. Thick secretions obstructed the airway, leading to the poor drainage of pus, and the formation of local abscesses leading to irresponsive to antibiotic therapy, which finally protracted recovery time. P. micra was successfully identified in bronchoalveolar lavage fluid (BALF) samples from all eight patients using tNGS; in contrast, sputum and BALF bacterial cultures yielded negative results, with P. micra cultured from only one empyema sample. Following appropriate antibiotic therapy, seven patients recovered. In previously documented cases, favorable outcomes were observed in 77.8% of individuals treated with antibiotics and 22.2% were cured after surgical interventions for P. micra lung abscesses.ConclusionsThis study enriches our understanding of the clinical characteristics associated with lung abscesses attributed to P. micra. Importantly, tNGS has emerged as a rapid and effective diagnostic test in scenarios where traditional sputum cultures are negative. Encouragingly, patients with lung abscesses caused by P. micra infection exhibit a favorable prognosis with effective airway clearance and judicious anti-infective management.

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