Furnishing Wound Repair by the Subcutaneous Fascia

Abstract

Mammals rapidly heal wounds through fibrous connective tissue build up and tissue contraction. Recent findings from mouse attribute wound healing to physical mobilization of a fibroelastic connective tissue layer that resides beneath the skin, termed subcutaneous fascia or superficial fascia, into sites of injury. Fascial mobilization assembles diverse cell types and matrix components needed for rapid wound repair. These observations suggest that the factors directly affecting fascial mobility are responsible for chronic skin wounds and excessive skin scarring. In this review, we discuss the link between the fascia’s unique tissue anatomy, composition, biomechanical, and rheologic properties to its ability to mobilize its tissue assemblage. Fascia is thus at the forefront of tissue pathology and a better understanding of how it is mobilized may crystallize our view of wound healing alterations during aging, diabetes, and fibrous disease and create novel therapeutic strategies for wound repair.

Resident T H 2 cells orchestrate adipose tissue remodeling at a site adjacent to infection

“…Dpp4 + Pi16 + stromal progenitors are a universal reservoir population containing cells capable of giving rise to differentiated fibroblast subsets ( 17 ) and adipocytes ( 16 , 18 ). These cells are localized to interstitial tissue, which is a fibroelastic connective tissue that envelops internal organs and blood vessels (where it is called the adventitia) and which is also found beneath the skin (where it is referred to as the fascia) ( 51 ). Evidence suggests continuity of interstitial tissue within and between organs, possibly providing a pathway for cell and antigen movement that is alternative to vascular or lymphatic routes ( 47 , 52 , 53 ).…”

[Retracted] Analysis of DAT Combined with the VSD Technique in Wound Repair of Rats and Its Effect on Inflammatory Factors

“…The cases of soft tissue trauma and burn caused by accidents are increasing year by year. Tissue damage can expose subcutaneous muscles, nerves, and bones in a large area, which not only increases the risk of infection but also damages patients' aesthetics, seriously reduces patients' quality of life, and causes great psychological pressure [ 1 , 2 ]. In the previous clinical repair of tissue trauma, traditional dressing change is mostly used for treatment, but this method could not meet the conditions required by the healing process of tissue trauma in patients and is prone to multiple complications.…”

Discussion: In Vivo Analysis of the Superficial and Deep Fascia

“…The absence of collective migration of fascia engrailed fibroblasts results in less scar formation. 8…”

“…The skin can develop a standard or hypertrophic scar by down-regulating or up-regulating cadherin expression. 7,8…”