Furo-1,2-naphthoquinones fromCrataegus pinnatifidawith ICAM-1 Expression Inhibition Activity

Abstract

Two new furo-1,2-naphthoquinones, crataequinones A (1) and B (2), were isolated from the fruits of Crataegus pinnatifida. The structures of two new compounds were determined as 11,12-dimethoxy-3,4-furo-1,2-naphthoquinone (1) and 11,12-dimethoxy-5-hydroxy-3,4-furo-1,2-naphthoquinone (2) by spectroscopic analysis. The two compounds 1 and 2 showed significant inhibitory activity with IC50 values of 33 and 90 microM, respectively, against the expression of intercellular adhesion molecule-1 (ICAM-1).

Design, synthesis, and evaluation of novel N'-substituted-1-(4-chlorobenzyl)-1H-indol-3-carbohydrazides as antitumor agents

“…Then, 20 ml of each compounds' samples, which were prepared as described above, were added to each well of the 96-well plates, which had been seeded with cell suspension and incubated for 24-h, at various concentrations. The plates were further incubated for 48 h. Cytotoxicity of the compounds was measured by the colorimetric method, as described previously 22 with slight modifications [23][24][25][26] . The IC 50 values were calculated using a probit method and were averages of three independent determinations (SD 10%) 27 .…”

Biological Properties and Antioxidant Activity of Hawthorn Crataegus mexicana

“…Determine if they act in an isolated way or the activity is increased when the present metabolites in the extract of "tejocote" are combined among them. It is necessary to design research on controlled clinical essays (cases and controls) [73][74][75] to evaluate its function, of the fruit, in humans, sick as well as healthy. Therefore propose new presentations of food products made upon a hawthorn base, that preserves its biological and antioxidant properties.…”

Isolation of Antithrombotic Phenolic Compounds from the Leaves of Crataegus pinnatifida

“…The genus Lygodium comprising 45 species is the sole genus of the family Lygodiaceae [1]. Previous phytochemical study on this genus was focused on species L. japonicum, L. circinnatum, and L. flexuosum, which led to the isolation of naphthoquinone [2], ecdysterosides [3], phenolic glycosides [4], antheridiogens [5,6], spiro furopyran-perhydrophenanthrene [7], and triterpenoids [8]. Lygodium japonicum (Thunb.)…”

“…Hawthorn, well-known as both a medicine and food material, is the common name of the plants in the genus Crataegus of the Rosaceae family, which are distributed in the Northern Hemisphere, mostly in China, Japan, South Korea, Europe, and North America. More than 1000 species of the genus have been described [1,2]. Currently, hawthorn leaves, flowers, and both green (unripe) and red (ripe) berries are used to make herbal preparations to treat patients with severe heart diseases, such as congestive heart failure, high blood pressure, hypoxia, and hyperlipemia [3,4].…”