Further blood genetic studies on Amazonian diversity—Data from four Indian groups

Callegari-Jacques, Sídia M.; Salzano, Francisco M.; Weimer, Tânia A.; Hutz, Mara H.; Black, Francis L.; Santos, Sidney; Guerreiro, João Farias; Mestriner, Moacyr Antonio; Pandey, Janardan P.

doi:10.1080/03014469400003482

Cited by 52 publications

(25 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The average G ST value obtained at these loci in the Colombian Amerindians (0.0584) was very similar to that obtained in six Caribbean-speaking Indian groups from Brazil (0.059) by Callegari-Jacques et al [94], and lower to that calculated in another five Brazilian Amerinds, by using six VNTR's loci (0.129) by Zago et al [32].…”

Section: Genetic Heterogeneitymentioning

confidence: 65%

Population Genetic Analysis of the Genes APOE, APOB (3′VNTR) and ACE in Some Black and Amerindian Communities from Colombia

Jaramillo‐Correa¹,

Keyeux²,

Ruiz‐García³

et al. 2001

Hum Hered

View full text Add to dashboard Cite

A population genetic study was carried out with the APOE, APOB and ACE loci in 17 Colombian human populations. Ten of them were Amerindian communities coming from the northeastern part of Colombia, Pacific region, Eastern Plains and Amazonia. Six were black populations from Providence Island, Caribbean and Pacific coasts. Finally, the Mestizo population of Bogota was studied as well. The APOE and ACE loci were in Hardy-Weinberg equilibrium, whereas the APOB locus was not studied in all populations. The genetic heterogeneity was substantially greater among the Amerindian populations (G_ST = 0.059) than in the Afrocolombian populations (G_ST = 0.009). Also the gene flow population pair estimates were so much higher among the Afrocolombian populations (Nm = 49.08 ± 43.07) than among Amerindian populations (Nm = 9.66 ± 18.04). Different phylogenetic and multivariant analyses showed that the Amerindian populations analyzed were clustered in three different arrays: one constituted by the Colombian northeastern and Pacific populations, the second one by the two Amazon populations (Coreguaje and Nukak) and the last one by the Yuco (the unique Caribbe-speaking population among those studied). The latter population was highly divergent from a genetic point of view from the remainder Amerindian populations studied. By using the Mantel test, the existence of a positive and significant correlation between the genetic and geographical distances found among Amerindian populations was demonstrated. This fact was not observed among the Afrocolombian populations. Nevertheless, an isolation-by-distance Slatkin analysis test did not show a significant clear structure of this special pattern among the Indian tribes studied.

show abstract

Section: Genetic Heterogeneitymentioning

confidence: 65%

Population Genetic Analysis of the Genes APOE, APOB (3′VNTR) and ACE in Some Black and Amerindian Communities from Colombia

Jaramillo‐Correa¹,

Keyeux²,

Ruiz‐García³

et al. 2001

Hum Hered

View full text Add to dashboard Cite

show abstract

“…A genetic basis for susceptibility and immunological response to rabies has been shown previously in mice 46–48. Although it is possible that certain isolated and remote populations in the Amazon region may be genetically and immunologically unique,49,50 two studies have also found signatures of gender-specific genetic admixture in certain Amazon populations and suggest that historical social policies have strongly influenced the migration of persons to and genetic mixing within the Amazon region 49,51. Genetic comparisons of immunological markers and relevant inducible responses (e.g., humoral and cellular response to rabies vaccination)52 from populations in urban areas and throughout the Amazon region of Perú may shed additional light on whether certain indigenous populations show evidence of natural selection for enhanced nonspecific or specific immunological responses and genetic resistance to rabies infection.…”

Section: Discussionmentioning

confidence: 99%

Evidence of Rabies Virus Exposure among Humans in the Peruvian Amazon

Gilbert¹,

Petersen²,

Recuenco³

et al. 2012

The American Society of Tropical Medicine and Hygiene

117

View full text Add to dashboard Cite

In May of 2010, two communities (Truenococha and Santa Marta) reported to be at risk of vampire bat depredation were surveyed in the Province Datem del Marañón in the Loreto Department of Perú. Risk factors for bat exposure included age less than or equal to 25 years and owning animals that had been bitten by bats. Rabies virus neutralizing antibodies (rVNAs) were detected in 11% (7 of 63) of human sera tested. Rabies virus ribonucleoprotein (RNP) immunoglobulin G (IgG) antibodies were detected in the sera of three individuals, two of whom were also seropositive for rVNA. Rabies virus RNP IgM antibodies were detected in one respondent with no evidence of rVNA or RNP IgG antibodies. Because one respondent with positive rVNA results reported prior vaccination and 86% (six of seven) of rVNA-positive respondents reported being bitten by bats, these data suggest nonfatal exposure of persons to rabies virus, which is likely associated with vampire bat depredation.

show abstract

“…While this subhaplogroup may have origins in the first migrants that came into the continent directly moving from the Atlantic coast into the Amazon (Callegari-Jacques et al 1994;Salzano and Callegari-Jacques 1988), further data from other South American groups will reveal whether it remains restricted to the region.…”

Section: Discussionmentioning

confidence: 99%

Identification of Whole Mitochondrial Genomes from Venezuela and Implications on Regional Phylogenies in South America

Lee¹,

Merriwether²

2015

Human Biology

View full text Add to dashboard Cite

Recent studies have expanded and refined the founding haplogroups of the Americas using whole mitochondrial (mtDNA) genome analysis. In addition to pan-American lineages, a number of studies have identified specific variants that show higher frequencies in restricted geographical areas. In order to further characterize Native American maternal lineages and specifically examine local patterns within South America, we analyzed twelve maternally unrelated Yekuana whole mtDNA genomes from one village (Sharamaña) that include the four major Native American haplogroups A2, B2, C1, and D1. Our study proposes a reconfiguration of one subhaplogroup A2 (A2aa) that is specific to South America and identifies other singleton 2 branches across the four haplogroups. Furthermore, we show nucleotide diversity values that increase from north to south for haplogroups C1 and D1. The results from our work add to the growing mitogenomic data that highlight local phylogenies and support the rapid genetic differentiation of South American populations, which has been correlated with the linguistic diversity in the region by previous studies.3

show abstract

Further blood genetic studies on Amazonian diversity—Data from four Indian groups

Cited by 52 publications

References 23 publications

Population Genetic Analysis of the Genes APOE, APOB (3′VNTR) and ACE in Some Black and Amerindian Communities from Colombia

Population Genetic Analysis of the Genes APOE, APOB (3′VNTR) and ACE in Some Black and Amerindian Communities from Colombia

Evidence of Rabies Virus Exposure among Humans in the Peruvian Amazon

Identification of Whole Mitochondrial Genomes from Venezuela and Implications on Regional Phylogenies in South America

Contact Info

Product

Resources

About