Further evidence for excitatory amino acid transmission in the lateral habenular projection to the rostral raphe nuclei: Lesion-induced decrease of high affinity glutamate uptake

Kalén, Peter; Pritzel, Monika; Nieoullon, A.; Wiklund, Leif

doi:10.1016/0304-3940(86)90225-9

Cited by 57 publications

(27 citation statements)

References 14 publications

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“…There is also evidence for a major EAA input to the DRN (Kalen et al, 1985(Kalen et al, , 1986, but the functional role of this input is unclear. In the present studies, the EAA antagonist KYN was used to investigate the role of this input in regulating the activity of DRN-5-HT neurons.…”

Section: Discussionmentioning

confidence: 99%

“…Microiontophoretic application of glutamate (GLU) activates DRN-5-HT neurons (VanderMaelen et al, 1986) and an autoradiographic study provided anatomical evidence for EAA projections to the DRN from several areas, with the most dense EAA projection originating in the lateral habenula (Kalen et al, 1985). In addition, lesions of the lateral habenula result in reduced high-affinity GLU uptake in the DRN, providing further evidence that the habenulo-raphe projection utilizes, at least in part, an EAA neurotransmitter (Kalen et al, 1986). Physiological evidence also supports this idea.…”

Section: Neurochemicalmentioning

confidence: 99%

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Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

1992

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Serotonergic (5-HT) neurons of the brainstem dorsal raphe nucleus (DRN) have been implicated in a diversity of physiological and behavioral processes in vertebrates. However, despite extensive information about the intrinsic properties and the efferent projections of this neurochemical system, little information is available regarding the afferents that control its activity. This study investigated the neurotransmitters that regulate the activity of DRN-5-HT neurons under physiologically relevant conditions, by utilizing microiontophoresis in combination with single-unit recordings in the awake, head-restrained cat. This made it possible to examine the direct effects of neurotransmitters on DRN-5-HT neuronal activity, and, through the use of specific antagonists, to study the roles of these neurotransmitter inputs during physiological conditions that influence DRN-5-HT neuronal activity. The results indicate that (1) iontophoretic application of the GABA antagonist bicuculline reversed the typical suppression of neuronal activity seen during slow wave sleep, but had no effect on maintained activity during wakefulness. The suppression of neuronal activity during REM sleep was generally unaffected by application of bicuculline. This suggests a role for a GABAergic input to DRN-5-HT neurons in controlling some aspects of their state-dependent activity. (2) Iontophoretic application of the excitatory amino acid (EAA) antagonist kynurenic acid reduced the magnitude of the neuronal response evoked by phasic auditory stimuli, but had no effect on the spontaneous activity of these neurons, suggesting a role for an EAA input to the DRN in mediating the response to phasic sensory stimuli.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 99%

Section: Neurochemicalmentioning

confidence: 99%

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

1992

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“…Inputs to the dorsal raphe and ventral midbrain originate from the same region of the LHb and appear to use glutamate/aspartate as a neurotransmitter (Kalen et al, 1985(Kalen et al, , 1986. LHb neurons are devoid of GAD65 mRNA but ex- press high levels of the vesicular glutamate transporter vGluT2 (Brinschwitz et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism

Shepard²

2007

Journal of Neuroscience

353

306

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“…The intrinsic property of the habenular cells that produces long-lasting discharges in response to transient synaptic hyperpolarization may render the medial part of the lateral habenula to function as an interface that converts inhibitory influences of the striatum and limbic forebrain into excitatory ones and conveys these excitatory influences to the midbrain. There is evidence that lateral habenular cells that project to the midbrain use excitatory amino acids as neurotransmitter (Kalen et al, 1985(Kalen et al, , 1986. The habenula may also convert a transient increase in the activity of the striatum and limbic forebrain into a persistent drive that prolongs action potential generation in downstream midbrain target neurons.…”

Section: The Maintenance and Termination Of The Ldapmentioning

confidence: 99%

Ionic Mechanism of Long-Lasting Discharges of Action Potentials Triggered by Membrane Hyperpolarization in the Medial Lateral Habenula

Su¹,

Kim²

2004

J. Neurosci.

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The activation of inhibitory synapses typically suppresses the generation of action potentials by hyperpolarizing the membrane of postsynaptic cells. In contrast to such conventional action of inhibitory synapses, we report here the ionic mechanism through which hyperpolarizing synapses trigger long-lasting discharges of action potentials that persist up to several tens of seconds. By using extracellular and intracellular recordings in slice preparations, we demonstrate that the activation of synaptic input from the limbic forebrain generates transient hyperpolarizing postsynaptic potentials in neurons of the medial part of the lateral habenular nucleus of the epithalamus. The synaptic hyperpolarization then sets off the coordinated activation of a distinct set of membrane ion channels and intracellular Ca 2ϩ mobilization by internal stores. The activation of these cellular events in distinct temporal order drives a persistent depolarization of habenular cells and promotes long-lasting discharges of tonic action potentials. The cells in the medial division of the lateral habenula project to dopamine and serotonin cells in the midbrain. We suggest that these habenular cells, by generating persistent action potentials in response to a transient increase in the activity of the limbic forebrain, may contribute to the regulation of the serotonergic and dopaminergic activity in the brain.

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Further evidence for excitatory amino acid transmission in the lateral habenular projection to the rostral raphe nuclei: Lesion-induced decrease of high affinity glutamate uptake

Cited by 57 publications

References 14 publications

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat

Lateral Habenula Stimulation Inhibits Rat Midbrain Dopamine Neurons through a GABAA Receptor-Mediated Mechanism

Ionic Mechanism of Long-Lasting Discharges of Action Potentials Triggered by Membrane Hyperpolarization in the Medial Lateral Habenula

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