Further experimental studies of the development of lateral‐line sense organs in amphibians observed in living preparations

Stone, L. S.

doi:10.1002/cne.900680105

Cited by 94 publications

(41 citation statements)

References 7 publications

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“…In the lateral line, regeneration occurs not only to renew lost HCs but also to renew whole neuromasts after they are removed, such as after tail amputation (Stone, 1937;Jones and Corwin, 1993;Dufourcq et al, 2006). In these instances, cells bud from the edge of existing neuromasts, proliferate, coalesce, and migrate to a new location to form new neuromasts in a manner recapitulating their development.…”

Section: Two Subpopulations Of Proliferating Cells Have Separate Funcmentioning

confidence: 99%

Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line

Y.¹,

Rubel²,

Raible³

2008

J. Neurosci.

228

336

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Section: Two Subpopulations Of Proliferating Cells Have Separate Funcmentioning

confidence: 99%

Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line

Y.¹,

Rubel²,

Raible³

2008

J. Neurosci.

228

336

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“…An additional cue to the origin of new cells comes from amputation studies. It has been shown in amphibians that amputation of the tip of the tail is followed by regeneration, and that a regenerated lateral line is formed by a new primordium that arises from the neuromast closest to the cut (Stone 1937). When the caudal fin is amputated in adult zebrafish (this is the only fin where neuromasts are present), a similar process of regeneration takes place (Dufourcq et al 2006).…”

Section: The Measure Of Growth: Neuromast Entelechiamentioning

confidence: 99%

The lateral line microcosmos

Ghysen¹,

2007

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The lateral-line system is a simple sensory system comprising a number of discrete sense organs, the neuromasts, distributed over the body of fish and amphibians in species-specific patterns. Its development involves fundamental biological processes such as long-range cell migration, planar cell polarity, regeneration, and postembryonic remodeling. These aspects have been extensively studied in amphibians by experimental embryologists, but it is only recently that the genetic bases of this development have been explored in zebrafish. This review discusses progress made over the past few years in this field.

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“…Early studies demonstrated that coldblooded animals, cartilaginous fish and toads, form new vestibular HCs as part of their normal body growth (Corwin, 1981;Corwin, 1985;Popper and Hoxter, 1984). In addition, HCs in the lateral line neuromasts are regenerated after tail amputation (Stone, 1933;Stone, 1937;Balak et al, 1990) or after laser-ablation of individual HCs (Jones and Corwin, 1993;1996). Remarkably, avian species also form new HCs in vestibular epithelia on an ongoing basis in reaction to normal HC apoptosis (Jørgensen and Mathiesen, 1988;Roberson et al, 1992;Kil et al, 1997) and rates of regeneration are increased upon HC damage (Weisleder and Rubel, 1993).…”

Section: Introductionmentioning

confidence: 99%

Hair cell regeneration in the avian auditory epithelium

Stone¹,

Cotanche²

2007

Int. J. Dev. Biol.

214

191

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Regeneration of sensory hair cells in the mature avian inner ear was first described just over 20 years ago. Since then, it has been shown that many other non-mammalian species either continually produce new hair cells or regenerate them in response to trauma. However, mammals exhibit limited hair cell regeneration, particularly in the auditory epithelium. In birds and other non-mammals, regenerated hair cells arise from adjacent non-sensory (supporting) cells. Hair cell regeneration was initially described as a proliferative response whereby supporting cells re-enter the mitotic cycle, forming daughter cells that differentiate into either hair cells or supporting cells and thereby restore cytoarchitecture and function in the sensory epithelium. However, further analyses of the avian auditory epithelium (and amphibian vestibular epithelium) revealed a second regenerative mechanism, direct transdifferentiation, during which supporting cells change their gene expression and convert into hair cells without dividing. In the chicken auditory epithelium, these two distinct mechanisms show unique spatial and temporal patterns, suggesting they are differentially regulated. Current efforts are aimed at identifying signals that maintain supporting cells in a quiescent state or direct them to undergo direct transdifferentiation or cell division. Here, we review current knowledge about supporting cell properties and discuss candidate signaling molecules for regulating supporting cell behavior, in quiescence and after damage. While significant advances have been made in understanding regeneration in nonmammals over the last 20 years, we have yet to determine why the mammalian auditory epithelium lacks the ability to regenerate hair cells spontaneously and whether it is even capable of significant regeneration under additional circumstances. The continued study of mechanisms controlling regeneration in the avian auditory epithelium may lead to strategies for inducing significant and functional regeneration in mammals.

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Further experimental studies of the development of lateral‐line sense organs in amphibians observed in living preparations

Cited by 94 publications

References 7 publications

Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line

Notch Signaling Regulates the Extent of Hair Cell Regeneration in the Zebrafish Lateral Line

The lateral line microcosmos

Hair cell regeneration in the avian auditory epithelium

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