Further Progress with Oncolysis due to Local High Frequency Hyperthermia, Local X-Irradiation and Apathogenic Clostridia<sup>*</sup>

Gericke, D; Dietzel, F; Rüster, I.

doi:10.1080/16070658.1979.11689147

Cited by 8 publications

(7 citation statements)

References 1 publication

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“…Similar observations were made by other authors combining local hyperthermia with the injection of BCG, Corynebacterium parvum [17] or apathogenic clostridia [23]. Immunogenicity of anti gens exposed after heating of tumor cells seems to be supported by these substances.…”

Section: Discussionsupporting

confidence: 75%

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Lersch¹,

Hammer²,

Ganghoff³

et al. 1984

Oncology

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Infrared contact coagulation (ICC) was evaluated in 3 different tumor models. 56–94% of all tumor-bearing rats, hamsters or mice were cured by ICC, whereas 100% of the controls died. The possibility that long-lasting immunological resistance might develop against the tumor after ICC was investigated by repeated tumor challenge. Cytotoxicity against tumor cells of host thymocytes and splenocytes following ICC was demonstrated in a Winn assay. The production of a mainly T-cell-dependent immune response could be due to ICC-induced antigenic changes in the tumor cells.

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Section: Discussionsupporting

confidence: 75%

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Lersch¹,

Hammer²,

Ganghoff³

et al. 1984

Oncology

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“…3–7 In mice that survive the treatment, there is tumor regrowth from well-oxygenated areas of the tumors, and even when this treatment is combined with chemotherapy or radiation therapy and hyperthermia, only partial tumor responses are detected. 8–10 The administration of Clostridium spores to human cancer patients has been described in 2 reports, 11,12 both of which indicated there was tumor lysis and abscessation.…”

mentioning

confidence: 99%

Evaluation of Clostridium novyi–NT spores in dogs with naturally occurring tumors

Krick¹,

Sørenmo²,

Rankin³

et al. 2012

ajvr

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Objective To establish the maximum tolerated dose of Clostridium novyi–NT spores in tumor-bearing dogs and evaluate spore germination within tumors and tumor response. Animals 6 client-owned dogs. Procedures A standard dose-escalation study was planned, with maximum tolerated dose defined as the highest dose at which 0 or 1 of 6 dogs had dose-limiting toxicoses (DLT). Dogs received 1 dose of C novyi–NT spores IV. Toxicoses were graded and interventions performed according to specific guidelines. Grade 3 or higher toxicosis or any toxicosis combination that substantially affected patient status was considered DLT. Clinical response was measured by use of response evaluation criteria in solid tumors at 28 days. Results The first 2 dogs had DLT. The dose was decreased. Two of the next 4 dogs had DLT; therefore, dose administration was stopped because the study endpoint had been reached. The most common toxicosis was fever (n = 6 dogs). Two dogs developed abscesses (1 within a nasal carcinoma and 1 splenic abscess) attributable to C novyi–NT infection; both required surgical intervention. Clostridium novyi–NT was cultured from 1 of 6 tumors. Five dogs were available for response assessment (4 had stable disease; 1 had progressive disease). Conclusions and Clinical Relevance Results indicated that C novyi–NT can germinate within tumors of dogs. Toxicosis, although common and sometimes severe, was manageable with treatment. Further studies in dogs with superficial tumors may allow for continued dose escalation and provide information for use in clinical trials in veterinary and human oncology.

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“…The combination of spore administration and various chemotherapeutic agents including 5-fluorodeoxyuridine and cyclophosphamide resulted in a more obvious reduction in tumour weight 40,41. Moreover, the combination of Clostridium spores with local irradiation and high-frequency hyperthermia increased the level of hypoxia in the tumour and led to an evident increase in the survival rate of mice bearing melanomas 42. The effectiveness of antitumour therapy could also be achieved by decreasing the oxygen level of the air breathed by tumour-bearing mice to only 11-12%.…”

Section: Bacteria Eliminating Tumours — History Mechanisms and Thmentioning

confidence: 99%

Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis

Wang¹,

Guo²,

Wu³

et al. 2019

J. Cancer

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As the human microbiota has been confirmed to be of great significance in maintaining health, the dominant bacteria in them have been applied as probiotics to treat various diseases. After the detection of bacteria in tumours, which had previously been considered a sterile region, these bacteria have been isolated and genetically modified for use in tumour therapy. In this review, we sum up the main types of bacteria used in tumour therapy and reveal the mechanisms of both wild type and engineered bacteria in eliminating tumour cells, providing potential possibilities for newly detected, genetically modified, tumour-associated bacteria in anti-tumour therapy.

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Further Progress with Oncolysis due to Local High Frequency Hyperthermia, Local X-Irradiation and Apathogenic Clostridia^*

Cited by 8 publications

References 1 publication

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Evaluation of Clostridium novyi–NT spores in dogs with naturally occurring tumors

Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis

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Further Progress with Oncolysis due to Local High Frequency Hyperthermia, Local X-Irradiation and Apathogenic Clostridia*

Cited by 8 publications

References 1 publication

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Infrared Contact Coagulation: A New Approach for Local Hyperthermic Therapy of Solid Animal Tumors

Evaluation of Clostridium novyi–NT spores in dogs with naturally occurring tumors

Oncolytic Bacteria and their potential role in bacterium-mediated tumour therapy: a conceptual analysis

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Further Progress with Oncolysis due to Local High Frequency Hyperthermia, Local X-Irradiation and Apathogenic Clostridia^*