Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology

Voshaar, Martijn A. H. Oude; Schenk, Olga; Klooster, Peter M. ten; Vonkeman, Harald E.; Moens, Hein J. Bernelot; Boers, Maarten; Laar, Mart A F J van de

doi:10.1002/acr.22793

Cited by 4 publications

(2 citation statements)

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“…These results are in keeping with previous papers where a different method to evaluate joint involvement such as the van der Heijdemodified Sharp erosion score (SvdH) was used [29,30]. The simplified version of the radiologic scores used here has been validated in previous studies [31,32] and their validity is further confirmed in our study. Regarding the other RA-related autoantibodies, we were not able to find any association between anti-PAD3 levels and joint damage, at variance from what has previously been reported by others [23,33], despite the similar cross-sectional approach.…”

Section: Discussionsupporting

confidence: 90%

Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis

et al. 2022

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Objectives Rheumatoid arthritis (RA) is a chronic inflammatory disease in which possible interstitial lung disease (ILD) is an extra-articular manifestation that carries significant morbidity and mortality. Rheumatoid Factors (RF) and anti-citrullinated protein antibodies (ACPA) are included in the RA classification criteria but prognostic and diagnostic biomarkers for disease endotyping and RA-ILD are lacking. Anti-protein arginine deiminase antibodies (anti-PAD) are a novel class of autoantibodies identified in RA. This study aimed to assess clinical features, ACPA, and anti-PAD antibodies in RA patients with articular involvement and ILD. Methods We retrospectively collected joint erosions, space narrowing, clinical features, and lung involvement of a cohort of seventy-one patients fulfilling the 2010 ACR/EULAR RA classification criteria. Serum samples from these patients were tested for ACPA IgG (QUANTA Flash CCP3), and anti-PAD3 and anti-PAD4 IgG, measured with novel assays based on a particle-based multi-analyte technology (PMAT). Results Anti-PAD4 antibodies were significantly associated with radiographic injury (p= 0.027) and erosions (p= 0.02). Similarly, ACPA levels were associated with erosive disease (p= 0.014). Anti-PAD3/4 double positive patients displayed more joint erosions than patients with anti-PAD4 antibodies only or negative for both (p= 0.014 and p= 0.037, respectively). RA-ILD (15.5%, 11/71 patients) was associated with older age (p< 0.001), shorter disease duration (p= 0.045) and less erosive disease (p= 0.0063). ACPA were elevated in RA-ILD, while anti-PAD4 were negatively associated (p= 0.043). Conclusion Anti-PAD4 and anti-PAD3 antibodies identify RA-patient with higher radiographic injury and bone erosions. In our cohort, ILD is associated with lower radiographic and erosive damage, as well as low levels of anti-PAD4 antibodies.

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Section: Discussionsupporting

confidence: 90%

Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis

et al. 2022

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“…We may need to explore other approaches than the various efforts to copy the SHS measures of wrist damage. This also raises the question "which joints can reliably and consistently provide information when the goal is to assess long-term 26 Further research and development of automated assessment of joint damage help to solve these issues.…”

Section: Discussionmentioning

confidence: 99%

Validation of automatic joint space width measurements in hand radiographs in rheumatoid arthritis

et al. 2016

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Abstract. Computerized methods promise quick, objective, and sensitive tools to quantify progression of radiological damage in rheumatoid arthritis (RA). Measurement of joint space width (JSW) in finger and wrist joints with these systems performed comparable to the Sharp-van der Heijde score (SHS). A next step toward clinical use, validation of precision and accuracy in hand joints with minimal damage, is described with a close scrutiny of sources of error. A recently developed system to measure metacarpophalangeal (MCP) and proximal interphalangeal (PIP) joints was validated in consecutive hand images of RA patients. To assess the impact of image acquisition, measurements on radiographs from a multicenter trial and from a recent prospective cohort in a single hospital were compared. Precision of the system was tested by comparing the joint space in mm in pairs of subsequent images with a short interval without progression of SHS. In case of incorrect measurements, the source of error was analyzed with a review by human experts. Accuracy was assessed by comparison with reported measurements with other systems. In the two series of radiographs, the system could automatically locate and measure 1003/1088 (92.2%) and 1143/1200 (95.3%) individual joints, respectively. In joints with a normal SHS, the average (SD) size of MCP joints was 1.7 AE 0.2 and 1.6 AE 0.3 mm in the two series of radiographs, and of PIP joints 1.0 AE 0.2 and 0.9 AE 0.2 mm. The difference in JSW between two serial radiographs with an interval of 6 to 12 months and unchanged SHS was 0.0 AE 0.1 mm, indicating very good precision. Errors occurred more often in radiographs from the multicenter cohort than in a more recent series from a single hospital. Detailed analysis of the 55/1125 (4.9%) measurements that had a discrepant paired measurement revealed that variation in the process of image acquisition (exposure in 15% and repositioning in 57%) was a more frequent source of error than incorrect delineation by the software (25%). Various steps in the validation of an automated measurement system for JSW of MCP and PIP joints are described. The use of serial radiographs from different sources, with a short interval and limited damage, is helpful to detect sources of error. Image acquisition, in particular repositioning, is a dominant source of error. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

et al. 2019

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Further Simplification of the Simple Erosion Narrowing Score With Item Response Theory Methodology

Cited by 4 publications

References 9 publications

Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis

Anti-protein arginine deiminase antibodies are distinctly associated with joint and lung involvement in rheumatoid arthritis

Validation of automatic joint space width measurements in hand radiographs in rheumatoid arthritis

Radiographic scoring methods in rheumatoid arthritis and psoriatic arthritis

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