Further Studies of the Anti-recall Effect of Lorazepam

Pandit, Sujit K.; Heisterkamp, David V.; Cohen, Peter J.

doi:10.1097/00000542-197611000-00005

Cited by 50 publications

(12 citation statements)

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“…These results confirm the amnesic effects reported with lorazepam by many authors (Pandit et al, 1976;George and Dundee, 1977;Dundee et al, 1979;Brown et af., 1982;Healey et al, 1983;Block and Berchou, 1984;Lister and File, 1984;Shader et al, 1986;Curran et af., 1987;Mattila et al, 1988;Preston et al, 1988) and the memory deficits observed in this study again demonstrate the difference between lorazepam and clobazam (Siegfried et al, 1981;Saletu et uf., 1985;Patat et al, 1988).…”

Section: Discussionsupporting

confidence: 91%

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Patat¹,

Klein²,

Surjus³

et al. 1991

Human Psychopharmacology

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This was a double-blind, placebo-controlled crossover study in 15 healthy female volunteers. It consisted of five sessions, separated by 1 week wash-out between sessions. The purpose of the trial was to study the potential amnesic and sedative activity of clobazam and lorazepam, and the potential antagonism between these effects under the joint influence of a high noise level and intense intermittent light stimulation (ILS), aimed at increasing the level of alertness. The study drugs were administered as a single daily oral dose. The amnesic and sedative effects were evaluated by objective measurements (digit span, Buschke selective reminding test, critical flicker fusion, reaction time, tapping, mental arithmetic test) and subjective measurements (visual analogue scale and adverse effect questionnaire) before each administration, then 1 h, 2 h, 2 5 h, 3 h, 4 h and 7 h post-dosing. An analysis of variance according to a balanced Latin square design was performed. Clobazam, at a dosage of 10 mg, was devoided of sedative and amnesic effects; at a dosage of 30 mg it induced only moderate memory disturbances. In contrast, lorazepam, administered at doses of 1 and 3 mg, produced marked and dose-dependent disturbances of memory, alertness and cognitive functions. The use of visual and sound stimuli, designed to increase the level of alertness, did not counteract the sedative effects induced by lorazepam.

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Section: Discussionsupporting

confidence: 91%

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Patat¹,

Klein²,

Surjus³

et al. 1991

Human Psychopharmacology

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“…As in the case of scopolamine, the amnestic properties of benzodiazepines were originally exploited in their use as pre-medication prior to anaesthesia (e.g., Clarke et al 1970;Pandit et al 1976), but it is now reeognised that they produce memory deficits even when given at low oral doses (e.g., Ghoneim and Mewaldt 1975). Lister (1985) has recently reviewed these effects of benzodiazepines and has concluded that the drugs impair specifically the acquisition of new information into secondary memory, but do Offprint requests to: G.C.…”

mentioning

confidence: 99%

Effects of lorazepam on memory, attention and sedation in man

et al. 1988

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The effects of three doses of lorazepam (0.5, 1.0 and 2.0 mg PO) on various aspects of memory, attention and sedation are described. Lorazepam produced dose-related deficits in verbal secondary memory, choice reaction time and a novel vigilance task. It also produced a dose-dependent increase in subjective sedation, and an enhancement of visual contrast sensitivity. These results are compared with those reported earlier using the muscarinic antagonist scopolamine, and discussed in relation to models of Alzheimer's disease.

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“…Its desirable properties include anxiolysis (Harry and Richards, 1972; Maleet al., 1980), anterograde amnesia (Wilson and Ellis, 1973;Pandit, Heisterkamp and Cohen, 1976), minimal effects on cardiovascular and respiratory systems (Cormack, Milledge and Harming, 1976;Dundee, Johnston and Gray, 1976) and the long duration of action makes the timing of premedication less crucial (Fragen and Caldwell, 1976).…”

Section: Discussionmentioning

confidence: 99%

Lorazepam in Children

Burtles¹,

Astley

1983

British Journal of Anaesthesia

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SUMMARYOne hundred patients aged 5-13yr were randomly allocated to four groups in a double-blind study of premedication. Drugs studied were lorazepam, diazepam and trimeprazine. A placebo group was included. All the drugs appeared satisfactory as premedicants. Lorazepam induced the most sedation immediately after surgery, but by 4 h lorazepam and diazepam appeared similar. Lorazepam produced better amnesia than the other drugs. There were no untoward side-effects and no cardiorespiratory depression in any group. Lorazepam appears a suitable premedicant for children.Lorazepam has been used successfully as an oral premedicant in adult patients (Paymaster, 1976; Dundee et al., 1977). Its desirable properties include anxiolysis (Harry and Richards, 1972; Maleet al., 1980), anterograde amnesia (Wilson and Ellis, 1973;Pandit, Heisterkamp and Cohen, 1976), minimal effects on cardiovascular and respiratory systems (Cormack, Milledge and Harming, 1976;Dundee, Johnston and Gray, 1976) and the long duration of action makes the timing of premedication less crucial (Fragen and Caldwell, 1976).In children (Boyd and Manford, 1973;Richardson and Manford, 1979;Beeby and Morgan Hughes, 1980) it is now accepted that the administration of premedication by mouth is safe, effective and preferred by the patient (Doughty, 1959). Lorazepam has been studied in children (Mundeleer, 1980) and appeared satisfactory. However, no comparison was made with an established drug.In the present study we have compared, in children, lorazepam, diazepam, trimeprazine and placebo as oral premedicants. PATIENTS AND METHODSOne hundred patients aged 5-13 yr were studied. The operations performed were mainly plastic surgical procedures, ENT operations or minor general surgical procedures. Children were drawn from three wards. Day cases were not included, nor were

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Further Studies of the Anti-recall Effect of Lorazepam

Cited by 50 publications

References 0 publications

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Study of effects of clobazam and lorazepam on memory and cognitive functions in healthy subjects

Effects of lorazepam on memory, attention and sedation in man

Lorazepam in Children

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