Further studies of the effects of intranigral morphine on behavioral responses to noxious stimuli

Baumeister, Alfred A.; Nagy, Marianne; Hebert, George; Hawkins, Mike F.; Vaughn, Angela; Chatellier, Maury O.

doi:10.1016/0006-8993(90)91326-c

Cited by 20 publications

(4 citation statements)

References 42 publications

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“…Evidence for this functional link has been provided by the physiological experiments in this study as well as previous studies (Kirouac and Pittman, 2000) showing that stimulation of the VTA/SN produces cardiovascular depressor responses that are mediated by a pathway to the PAGvl/DR. There is also considerable evidence that the VTA/SN play a role in pain modulation (Jurna et al, 1978; Barnes et al, 1979; Baumeister and Frye, 1986; Frye et al, 1986; Baumeister et al, 1987; Baumeister et al, 1988, 1989, 1990, 1993; Hebert et al, 1990; Morgan and Franklin, 1990; Baumeister, 1991; Altier and Stewart, 1993, 1996, 1997, 1998). At the present, there is no evidence that antinociception elicited by activation of neurons in the VTA/SN is mediated by a projection to the PAGvl/DR.…”

Section: Functional Considerationsmentioning

confidence: 99%

“…An anatomic projection from the VTA/SN to the PAGvl/DR is of potential importance because of several investigations reporting that the VTA and SN play a role in modulating pain and arterial blood pressure, two functions that are also regulated by the PAGvl/DR (Lovick, 1993; Bandler and Shipley, 1994; Behbehani, 1995; Bandler et al, 2000). For example, injections of γ‐aminobutyric acid (GABA) agonists or morphine into the SN have antinociceptive effects in anesthetized and conscious rats (Jurna et al, 1978; Barnes et al, 1979; Baumeister and Frye, 1986; Frye et al, 1986; Baumeister et al, 1987, 1988, 1989, 1990, 1993; Baumeister, 1991; Hebert et al, 1990). Injections of morphine or substance P into the VTA also elicit antinociception (Altier and Stewart, 1993, 1996, 1997, 1998; Morgan and Franklin, 1990).…”

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confidence: 99%

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GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus

Kirouac

Mabrouk

2003

J of Comparative Neurology

111

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Previous studies have shown that neurons in the ventral tegmental area (VTA) and substantia nigra (SN) project to the ventrolateral periaqueductal gray (PAGvl) and dorsal raphe nucleus (DR). Research has also shown that stimulation of neurons in the VTA/SN elicits cardiovascular depressor responses that are mediated by a projection to the PAGvl/DR. Anatomic and physiological experiments were done in the present study to determine the neurochemical identity of the VTA/SN projection to the PAGvl/DR. Experiments were done to characterize the origin and chemical nature of this projection by combining cholera toxin B tracing with immunofluorescence for the 67K isoform of glutamic acid decarboxylase (GAD) and tyrosine hydroxylase. The PAGvl/DR region was found to receive a substantial input from neurons in the VTA, SN, and deep mesencephalic nucleus. The DR was preferentially innervated by neurons in the VTA, whereas the PAGvl was preferentially innervated by neurons in the SN. A proportion of neurons in the VTA and the reticular portion of the SN found to project to the PAGvl/DR were GAD positive. In addition, experiments were done in urethane-anesthetized rats to determine whether injections of a gamma-aminobutyric acid (GABA) antagonist in the region of the PAGvl/DR attenuated the cardiovascular depressor responses produced by glutamate stimulation of the VTA/SN. Injections of the GABA-blocking agent picrotoxin (2.5 nmol, 500 nl) into the PAGvl/DR eliminated the cardiovascular responses from stimulation of the VTA/SN (0.01 M, 50 nl). The results of the present investigation provide evidence for a GABAergic projection from the VTA/SN to the PAGvl/DR. This projection may be an important regulator of the PAGvl/DR, an area of the midbrain involved in the production of behavioral and physiological responses to pain and stress.

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Section: Functional Considerationsmentioning

confidence: 99%

mentioning

confidence: 99%

GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus

Kirouac

Mabrouk

2003

J of Comparative Neurology

111

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“…Animal models have shown that dopamine depletion leads to increased responses to nociception and somatosensory input, including MPTP [22] and intrastriatal 6-OHDA models [23] [24]. Electrolytic lesions of the substantia nigra have been observed to reduce analgesic effects of morphine [25]. Previous studies in cats [26] and rodents [27] [28] have shown that the basal ganglia are important in the integration of motor and sensory input, which may play a role in coordination.…”

Section: Discussionmentioning

confidence: 99%

Central Pain in Parkinson’s Disease: A Case Report

Moon¹,

Lin²,

Rosner³

2018

CRCM

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Pain in Parkinson's disease is common, with an estimated prevalence up to 85% of those with the disease. Central pain in Parkinson's disease is poorly understood and the role of pharmacological treatment, including the use of dopamine agonists, needs further investigation. Our objective is to discuss a case report of central pain in Parkinson's disease in an outpatient setting. A 67-year-old-male patient with Parkinson's disease presented with right-sided pain, which was refractory to non-steroidal anti-inflammatory drugs, acetaminophen, and opioid agonists. The initiation of dopaminergic therapy resulted in a near complete relief of pain. This case illustrates the need for a multidisciplinary approach to better care for Parkinson's disease patients with central pain, and further study to identify the pathophysiologic mechanism.

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“…These receptors are also involved in pain processing by the BG. For example, microinjection of morphine into the substantia nigra (SN), without producing motor impairment, suppressed pain-related behavior in the hot-plate test (Baumeister et al, 1990). In addition, naloxone-sensitive antinociception has been reported following microinjection of morphine into the pallidum (Anagnostakis et al ., 1992).…”

Section: Introductionmentioning

confidence: 99%

Histamine and its H1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors

Asgharieh-Ahari¹,

Tamaddonfard²,

Erfanparast³

et al. 2023

Behavioural Pharmacology

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Many structures of the central nervous system recruit different neurotransmitters in pain processing. This study focused on the contribution of histamine and its H 1 receptors in the ventral pallidum (VP) in mediating paintriggered behaviors. Intra-VP microinjection of histamine and 2-pyridylethylamine (2-PEA, a histamine H 1 receptor agonist) at the same doses of 0.5 and 1 µg/200 nl reduced both the first and second phases of licking/biting duration as well as flinching number induced by intra-plantar (ipl) injection of formalin (2.5%, 50 µl). Premicroinjection of mepyramine (a histamine H 1 antagonist, 2 µg/200 nl) into the VP antagonized the suppressive effects of 1 µg/200 nl histamine and 2-PEA on licking/biting and flinching behaviors. The possible mechanisms of the above-mentioned pain-reducing effects were followed by intra-VP and intrathecal administration of naloxone (an opioid receptor antagonist). Naloxone (2 µg/200 nl) preadministration into the VP inhibited attenuating effects of histamine and 2-PEA on both the licking/biting and flinching behaviors, whereas intrathecal injection of naloxone only inhibited their suppressing effects on flinching behavior. None of the treatments used in this study altered the animal's motor activity. The obtained results may reveal the role of histamine and its activated H 1 receptor in the VP in suppressing the pain behaviors caused by formalin. Opioid receptors in the VP and spinal cord may contribute to these functions. Behavioural Pharmacology 34: 457-467

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Further studies of the effects of intranigral morphine on behavioral responses to noxious stimuli

Cited by 20 publications

References 42 publications

GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus

GABAergic projection from the ventral tegmental area and substantia nigra to the periaqueductal gray region and the dorsal raphe nucleus

Central Pain in Parkinson’s Disease: A Case Report

Histamine and its H1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors

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