Further studies on sperm-immobilizing antibody found in sera of unexplained cases of sterility in women

Sperm Immobilizing Antibodies Interfere With Sperm Migration From the Uterine Cavity through the Fallopian Tubes

“…It is well established that sperm immobilizing antibodies are found specifically in the sera of sterile women with unknown cause. 1,2 And it is also well known that sperm migration through cervical mucus (CM) is impaired by sperm immobilizing antibodies secreted in the CM. 3 Patients with the antibodies are less likely to conceive even with intra-uterine insemination (IUI),4but it has not yet been clarified whether sperm migration from the uterine cavity through the fallopian tubes to the peritoneal cavity is impaired by the antibodies.…”

Serum Sperm Antibodies in Cases of Azoospermia: Comparative Diagnostic Value of Separate and Combined, Agglutination, Immobilization and Cytotoxic Serological Tests

“…detected by Kibrick test are IgG (Boettcher et al -1971) and are completely absorbed by sperms (Fjallbrant -1968b) while agglutinins detected by the immobilization test are both IgC and IgM (Isojima et al -1972) and are only partly absorbed by sperms (Fjallbrant -1968b). Substances detected by the micro agglutination test of Franklin and Dukes are partly B globulins (Boettcher e t al.…”

Etiological Implication of Autoantibodies to Zona Pellucida in Human Female Infertility

“…To avoid misassessment of anti-fertility effects by antisperm antibodies whose inhibitory effect on sperm-egg interaction was demonstrated.l'v'? all the PHAR-positive serum samples were checked for sperm immobilizing activities by the method oflsojima et al 21…”