Further Studies on the Association between Human Serum Phosphatases and Blood Groups

Plasma alkaline phosphatase isoenzymes in hepatobiliary disease

“…Their patients were of blood groups B and 0: other series (Kaplan and Rogers, 1969) have confirmed their finding. The intestinal band has been reported in normal subjects of blood groups B and 0 (Arfors et al, 1963;Bamford, Harris, Luffman, Robson, andCleghorn, 1965): Beckmann (1964) related this to ABH secretor status. The presence of intestinal isoenzyme is also related to diet, the ingestion of fat elevating the intestinal isoenzyme level in the sera of blood group 0 secretor individuals (Langman, Leuthold, Robson, Harris, Luffman, and Harris, 1966;Walker, Eze, Tweedie, and Evans, 1971).…”

“…Four major isoenzymes of alkaline phosphatase (orthophosphoric-monoester phosphohydrolase: EC 3.1.3.1) have been known for some time and can be easily separated in normal and abnormal serum: they are produced respectively by liver parenchyma, placenta, intestinal mucosa, and osteoblasts (Arfors, Beckman, and Lundin, 1963;Green, Cantor, Inglis, and Fishman, 1972;Fishman, Bardawil, Habib, Anstiss, and Green, 1972). The predominant liver isoenzyme is 'slow' or '0X2'.…”

Alkaline Phosphatase Isoenzymes

“…This is because the genetic predisposition of certain individuals to show a small amount of intestinal phosphatase in their serum, even in health [26], appears to operate also in disease, so that patients with this trait are more likely to have an increased intestinal alkaline phosphatase activity in the serum in diseases of the liver or intestinal tract than those not so predisposed : in other words, the presence of intestinal alkaline phosphatase in serum is not related solely to particular pathological states. However, intestinal phosphatase in serum is readily separated from other alkaline phosphatases, and so does not interfere with the interpretation of changes in the amounts of liver or bone phosphatase present, for example.…”

Genetically Determined Variants of Serum Alkaline Phosphatase: A Review

“…Arfors, Beckman and Lundin [2,3] made the initial observation that an individual's phosphatase phenotype is related to his ABO blood type and his secretor status. Most, if not all, individuals with B zone activity are salivary secretors of the ABH blood group substances, and the presence of the B zone is strongly negatively correlated with the presence of blood group A.…”