Further Studies on the Mode of Transmission of Herpes-Like Virus in Guinea Pigs

Lam, K. M.; Hsiung, G. D.

doi:10.3181/00379727-138-35911

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…9 appeared to have more virus in its tissues than rabbit no. 7. No virus was isolated from the blood of any of the four rabbits at the time of sacrifice.…”

Section: Resultsmentioning

confidence: 99%

“…In the preceding paper we described the antibody response to and virus persistence of a guinea pig herpes-like virus (GPHLV) in its natural host, the guinea pig. Once infected with this virus, either naturally or experimentally, guinea pigs produced viral-specific neutralizing antibody while infectious virus continued to be readily isolated from the blood (5)(6)(7). Infected guinea pigs showed no apparent sign of illness, nor were any nuclear inclusions detectable in their tissues.…”

mentioning

confidence: 99%

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Guinea Pig Herpes-Like Virus Infections II. Antibody Response and Virus Persistence in Mice and Rabbits

Lam

Hsiung

1973

Infect Immun

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Mice inoculated with guinea pig herpes-like virus produced minimal, if any, antibody response, and no virus was isolated from the inoculated animals 64 days after administration. The antibody response in rabbits inoculated with the same virus was prompt and reached a high level within 14 to 29 days regardless of the site of inoculation. Long-term persistence of viremia was observed only in intravenously inoculated rabbits; a brief period of viremia was observed in intraperitoneally inoculated rabbits, but no viremia was obtained in rabbits inoculated by the subcutaneous route. Maternal antibody was transferred readily to offspring; however, transference of infectious virus from mother to offspring was demonstrable in only one of 75 fetuses tested.

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“…9 appeared to have more virus in its tissues than rabbit no. 7. No virus was isolated from the blood of any of the four rabbits at the time of sacrifice.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Guinea Pig Herpes-Like Virus Infections II. Antibody Response and Virus Persistence in Mice and Rabbits

Lam

Hsiung

1973

Infect Immun

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“…A herpes-like virus originally isolated from leukemic strain 2 guinea pigs was found to be present in a high percentage of inbred strain 2 guinea pigs (2,6,9) and, in a few instances, in Muta strain animals, but rarely in the randombred Hartley strain (6). Subsequently, it was found that the virus can multiply in Hartley guinea pigs after experimental infection (3,7,8). The virus was maintained at a stable level in the blood of inoculated guinea pigs for life after an initial period of virus multiplication.…”

mentioning

confidence: 99%

Guinea Pig Herpes-Like Virus Infection I. Antibody Response and Virus Persistence in Guinea Pigs After Experimental Infection

Lam

Hsiung

1973

Infect Immun

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Guinea pigs, experimentally infected with guinea pig herpes-like virus produced antibodies which were detectable by indirect hemagglutination (IHA), complement-fixation (CF), and neutralization tests. The IHA test appeared to be a more sensitive method than the CF or neutralization test for determining antibody response in guinea pigs immediately after infection, but the IHA method was not suitable for the detection of antibody in animals receiving small doses of virus. Antibody titers obtained by CF tests were generally higher than those obtained by the neutralization test, and they followed the same time course when individual aniimals were studied serially. Intracardiac inoculation produced the best antibody response in guinea pigs when compared with other routes of infection. Guinea pigs infected by the intraperitoneal, intranasal, or oral route showed rising antibody titers but the levels were low. Infectious virus was isolated from and persisted in all inoculated animals in the presence of antibody regardless of the route of inoculation. Recovery of infectious virus required cultivation or cocultivation of tissue cells containing virus. The administration of antilymphocyte sera delayed the appearance of IHA antibody but had no effect on antibodies determined by the CFand neutralization tests.

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“…Several reports have been concerned with the increased incidence of lymphoproliféra tive disorders in organ transplant patients under cyclosporin A (CsA) immunosuppres sion [1][2][3][4], and the causative role of Epstein-Barr virus (EBV) infection in the develop ment of these disorders is suspected [5][6][7][8], Guinea pig lymphotropic herpesvirus (GPHLV), a virus with possible relevance to EBV, has been studied in experimentally in fected guinea pigs in our laboratory over years [9][10][11][12][13][14], In the present study, the effect of CsA upon the pathogenesis of primary GPHLV infection in the guinea pig model was investigated under circumstances which simulated the acquisition of the virus in fection during an immunosuppressed state.…”

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Effect of Cyclosporin A Immunosuppression on Primary Lymphotropic Herpesvirus Infection in the Guinea Pig

Nagy-Oltvai

Jennings²,

Brady³

et al. 1987

Intervirology

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Female guinea pigs pretreated for 2 days with cyclosporin A (CsA), were then inoculated intranasally (IN) or intraperitoneally (IP) with a lymphotropic herpesvirus (GPHLV) and followed by 4 additional daily doses of CsA. Immunosuppressed animals did not show lymphocytosis and virus infectivity titers in their spleen, cervical lymph node and blood mononuclear cells were lower than those of oil-treated controls. While IN-inoculated CsA-treated animals expressed higher virus infectivity titer in their lungs compared to oil-treated controls, this difference was not seen in the IP-inoculated groups. At histopatho-logy, lymphoid depletion was seen in all CsA-treated animals, but lymphocytic interstitial pneumonia was observed only in the lungs of IN-inoculated CsA-treated guinea pigs. Thus, CsA immunosuppression altered the pathogenesis of primary GPHLV infection with some notable differences attributed to the route of virus inoculation.

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Further Studies on the Mode of Transmission of Herpes-Like Virus in Guinea Pigs

Cited by 6 publications

References 3 publications

Guinea Pig Herpes-Like Virus Infections II. Antibody Response and Virus Persistence in Mice and Rabbits

Guinea Pig Herpes-Like Virus Infections II. Antibody Response and Virus Persistence in Mice and Rabbits

Guinea Pig Herpes-Like Virus Infection I. Antibody Response and Virus Persistence in Guinea Pigs After Experimental Infection

Effect of Cyclosporin A Immunosuppression on Primary Lymphotropic Herpesvirus Infection in the Guinea Pig

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