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The newly isolated Sheridan-83 strain of duck enteritis virus (DEV) was apathogenic to ducks. Inoculation of ducks with this virus resulted in the production of antibodies that enabled the ducks to resist challenge with the virulent LA strain of DEV. The minimum protective dose of the Sheridan-83 virus was determined to be less than 10 TCID50. Solid immunity lasted 1-2 months. Passive transfer of antibodies to susceptible ducks also significantly protected them from lethal challenge.

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A herpesvirus isolated from waterfowl dying of duck enteritis (DE) was tentatively designated the Sheridan-83. It was serologically related to the original Holland and Lake Andes (LA) strains of duck enteritis viruses (DEV). Other biological characteristics indicated that the Sheridan-83 was more closely related to the Holland strain than to the LA virus. The Sheridan-83 was nonpathogenic to ducks, and ducks inoculated with this virus developed resistance to challenge with the virulent strain LA.