Further study of the effect of particle size on slow particle clearance from the bronchial tree

Smith, Jennifer; Bailey, Michael R.; Etherington, G.; Shutt, A. L.; Youngman, M. J.

doi:10.1093/rpd/ncm401

Cited by 9 publications

(7 citation statements)

References 3 publications

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“…The geometric diameter d p of the Teflon was smaller (4.5 µm) than that of the PSL (6.1 µm), and the HRTM predicts f s to be greater (14% vs 5%). However, retention of the two particles was similar in each subject. (A24) Smith et al. (2007, 2008) tested these alternative hypotheses more critically, also administering two particles of the same d ae , but with a greater difference in densities and as shallow boluses to minimise alveolar deposition.…”

Section: Annex a Revision Of The Human Respiratory Tract Modelmentioning

confidence: 99%

“…(A24) Smith et al. (2007, 2008) tested these alternative hypotheses more critically, also administering two particles of the same d ae , but with a greater difference in densities and as shallow boluses to minimise alveolar deposition.…”

Section: Annex a Revision Of The Human Respiratory Tract Modelmentioning

confidence: 99%

“…However, retention of the two particles was similar in each subject. (A24) Smith et al (2007Smith et al ( , 2008 tested these alternative hypotheses more critically, also administering two particles of the same d ae , but with a greater difference in densities and as shallow boluses to minimise alveolar deposition. In one study, volunteers inhaled 5-mm d ae PSL and gold (r ¼ 19.3 g cm À3 ) particles; corresponding d p values were 5 and 1.2 mm, and values of f s were approximately 10% and 50%, respectively.…”

Section: A22 Particle Transport: Bronchial and Bronchiolar Airwaysmentioning

confidence: 99%

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ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

Paquet¹,

et al. 2015

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This report is the first in a series of reports replacing Publications 30 and 68 to provide revised dose coefficients for occupational intakes of radionuclides by inhalation and ingestion. The revised dose coefficients have been calculated using the Human Alimentary Tract Model (Publication 100) and a revision of the Human Respiratory Tract Model (Publication 66) that takes account of more recent data. In addition, information is provided on absorption into blood following inhalation and ingestion of different chemical forms of elements and their radioisotopes. In selected cases, it is judged that the data are sufficient to make material-specific recommendations. Revisions have been made to many of the models that describe the systemic biokinetics of radionuclides absorbed into blood, making them more physiologically realistic representations of uptake and retention in organs and tissues, and excretion. The reports in this series provide data for the interpretation of bioassay measurements as well as dose coefficients, replacing Publications 54 and 78. In assessing bioassay data such as measurements of whole-body or organ content, or urinary excretion, assumptions have to be made about the exposure scenario, including the pattern and mode of radionuclide intake, physical and chemical characteristics of the material involved, and the elapsed time between the exposure(s) and measurement. This report provides some guidance on monitoring programmes and data interpretation.

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Section: Annex a Revision Of The Human Respiratory Tract Modelmentioning

confidence: 99%

Section: Annex a Revision Of The Human Respiratory Tract Modelmentioning

confidence: 99%

Section: A22 Particle Transport: Bronchial and Bronchiolar Airwaysmentioning

confidence: 99%

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ICRP Publication 130: Occupational Intakes of Radionuclides: Part 1

Paquet¹,

et al. 2015

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“…More recent studies (8) have tested these alternative hypotheses more critically, by (i) administering particles with the same d ae , but with a greater difference in densities; (ii) using the shallow bolus technique to minimise alveolar deposition and (iii) administering the two particles simultaneously, to ensure that deposition and clearance take place under the same conditions. In the first study, volunteers inhaled shallow boluses containing 5-mm d ae PSL and gold (r ¼ 19.3 g cm 23 ) particles.…”

Section: Particle Transport: Bb and Bb Airwaysmentioning

confidence: 99%

Updating the ICRP human respiratory tract model

Bailey¹,

Ansoborlo

Guilmette

et al. 2007

Radiation Protection Dosimetry

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The ICRP Task Group on Internal Dosimetry is developing new Occupational Intakes of Radionuclides (OIR) documents. Application of the Human Respiratory Tract Model (HRTM) requires a review of the lung-to-blood absorption characteristics of inhaled compounds of importance in radiological protection. Where appropriate, material-specific absorption parameter values will be given, and for other compounds, assignments to default Types will be made on current information. Publication of the OIR provides an opportunity for updating the HRTM in the light of experience and new information. The main possibilities under consideration relate to the two main clearance pathways. Recent studies provide important new data on rates of particle transport from the nasal passages, bronchial tree (slow phase) and alveolar region. The review of absorption rates provides a database of parameter values from which consideration can be given to deriving typical values for default Types F, M and S materials, and element-specific rapid dissolution rates.

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“…(619) Smith et al (2007Smith et al ( , 2008 followed lung retention of 198 Au-labelled gold particles for up to $10 d after inhalation by volunteers as an aerosol bolus at the end of each breath to minimise alveolar deposition. The aim of the study was to investigate the effect of particle diameter on clearance from the bronchial tree.…”

Section: Dosimetric Data For Platinummentioning

confidence: 99%