Fusarielin E, a new antifungal antibiotic from Fusarium sp.

Gai, Yue; Zhao, Ling; Hu, Chun; Zhang, Huiping

doi:10.1016/j.cclet.2007.05.048

Cited by 33 publications

(9 citation statements)

References 3 publications

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“…1H3-M3-P1(2) species. Marine species of Penicillium and Fusarium genera have already been described as producers of antifungal terpenoids like penicisteroids and polyketides as fusarielin E, respectively [ 33 , 34 , 35 , 36 , 37 , 38 ]. Marine-derived Paecilomyces species, isolated from mangrove habitats, have been shown to produce antifungal polyketides [ 39 , 40 ].…”

Section: Resultsmentioning

confidence: 99%

Deep Subseafloor Fungi as an Untapped Reservoir of Amphipathic Antimicrobial Compounds

et al. 2016

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The evolving global threat of antimicrobial resistance requires a deep renewal of the antibiotic arsenal including the isolation and characterization of new drugs. Underexplored marine ecosystems may represent an untapped reservoir of novel bioactive molecules. Deep-sea fungi isolated from a record-depth sediment core of almost 2000 m below the seafloor were investigated for antimicrobial activities. This antimicrobial screening, using 16 microbial targets, revealed 33% of filamentous fungi synthesizing bioactive compounds with activities against pathogenic bacteria and fungi. Interestingly, occurrence of antimicrobial producing isolates was well correlated with the complexity of the habitat (in term of microbial richness), as higher antimicrobial activities were obtained at specific layers of the sediment core. It clearly highlights complex deep-sea habitats as chemical battlefields where synthesis of numerous bioactive compounds appears critical for microbial competition. The six most promising deep subseafloor fungal isolates were selected for the production and extraction of bioactive compounds. Depending on the fungal isolates, antimicrobial compounds were only biosynthesized in semi-liquid or solid-state conditions as no antimicrobial activities were ever detected using liquid fermentation. An exception was made for one fungal isolate, and the extraction procedure designed to extract amphipathic compounds was successful and highlighted the amphiphilic profile of the bioactive metabolites.

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Section: Resultsmentioning

confidence: 99%

Deep Subseafloor Fungi as an Untapped Reservoir of Amphipathic Antimicrobial Compounds

et al. 2016

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“…were reported to produce structurally diversified antimicrobial compounds [ 27 – 35 ], and three marine derived Fusarium spp. were also been reported to produce the novel antibacterial cyclodepsipeptide enniatin B [ 36 ], the sesterterpene neomangicol B [ 37 ], and the antifungal compound fusarielin E [ 38 ], which revealed the potential of fungi of genus Fusarium as producers of abundant novel antibiotics, so the F. oxysporum isolate DLEP2008005 derived from sponge was also expected to be a good antibiotic-producer candidate.…”

Section: Resultsmentioning

confidence: 99%

Broad-Spectrum Antimicrobial Epiphytic and Endophytic Fungi from Marine Organisms: Isolation, Bioassay and Taxonomy

et al. 2009

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In the search for new marine derived antibiotics, 43 epi- and endophytic fungal strains were isolated from the surface or the inner tissue of different marine plants and invertebrates. Through preliminary and secondary screening, 10 of them were found to be able to produce broad-spectrum antimicrobial metabolites. By morphological and molecular biological methods, three active strains were characterized to be Penicillium glabrum, Fusarium oxysporum, and Alternaria alternata.

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“…In the present study we have identified three novel members of the fusarielin family, in addition to the already known fusarielins A‐E (Fig. 7) isolated from two unknown Fusarium species (Kobayashi et al ., 1995; Gai et al ., 2007). Fusarielin E was also isolated from an Aspergillus sp.…”

Section: Discussionmentioning

confidence: 99%

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum

Sørensen

Hansen

Søndergaard

et al. 2012

Environmental Microbiology

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Like many other filamentous fungi, Fusarium graminearum has the genetic potential to produce a vast array of unknown secondary metabolites. A promising approach to determine the nature of these is to activate silent secondary metabolite gene clusters through constitutive expression of cluster specific transcription factors. We have developed a system in which an expression cassette containing the transcription factor from the targeted PKS cluster disrupts the production of the red mycelium pigment aurofusarin. This aids with identification of mutants as they appear as white colonies and metabolite analyses where aurofusarin and its intermediates are normally among the most abundant compounds. The system was used for constitutive expression of the local transcription factor from the PKS9 cluster (renamed FSL) leading to production of three novel fusarielins, F, G and H. This group of compounds has not previously been reported from F. graminearum or linked to a biosynthetic gene in any fungal species. The toxicity of the three novel fusarielins was examined against colorectal cancer cell lines where fusarielin H was more potent than fusarielin F and G.

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Fusarielin E, a new antifungal antibiotic from Fusarium sp.

Cited by 33 publications

References 3 publications

Deep Subseafloor Fungi as an Untapped Reservoir of Amphipathic Antimicrobial Compounds

Deep Subseafloor Fungi as an Untapped Reservoir of Amphipathic Antimicrobial Compounds

Broad-Spectrum Antimicrobial Epiphytic and Endophytic Fungi from Marine Organisms: Isolation, Bioassay and Taxonomy

Production of novel fusarielins by ectopic activation of the polyketide synthase 9 cluster in Fusarium graminearum

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