Fusobacterium necrophorum, an emerging pathogen of otogenic and paranasal infections?

Creemers-Schild, Dina; Gronthoud, Firza Alexander; Spanjaard, Lodewijk; Visser, Leo G.; Brouwer, Carole N. M.; Kuijper, Ed J.

doi:10.1002/nmi2.39

Cited by 39 publications

(44 citation statements)

References 31 publications

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“…Invasive disease due to F. nucleatum is, however, more frequent in patients with chronic diseases [6,8]. We found, as have other investigators, that severe infections due to Fusobacterium in healthy individuals are usually caused by F. necrophorum-among them, CSVT, mastoiditis and abscesses [8,9,11,34]. Treatment modalities in our series included antibiotics, anti-coagulation therapy and surgical intervention.…”

Section: Discussionmentioning

confidence: 52%

“…We demonstrated, however, that severe overwhelming infection can occur, as in one patient, who died shortly after admission. Unfavorable outcome in five children with otogenic and paranasal infections was reported recently, only two patients recovered completely, one patient died due to complications of the infection, one patient retained a slight hemiparesis and one patient had permanent hearing loss [34].…”

Section: Discussionmentioning

confidence: 98%

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Infections caused by Fusobacterium in children: a 14-year single-center experience

et al. 2015

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Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 98%

Infections caused by Fusobacterium in children: a 14-year single-center experience

et al. 2015

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“…In some cases, it can lead to invasive head and neck infections such as sinusitis, peritonsillar abscesses or mastoiditis . The increase in the incidence of Fusobacterium mastoiditis, particularly in healthy children, has been documented by several authors over the last decade . Clinicians need to be aware of this rise since cerebral complications in acute Fusobacterium mastoiditis, particularly septic thrombosis, are not rare.…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium necrophorum, a major provider of sinus thrombosis in acute mastoiditis: A retrospective multicentre paediatric study

Coudert

Fanchette

Regnier

et al. 2019

Clinical Otolaryngology

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Objective To evaluate in children the clinical severity and evolution of otogenic lateral sinus thrombosis (OLST) due to Fusobacterium necrophorum compared with other bacterial otogenic thrombosis and propose a specific management flowchart for Fusobacterium OLST. Design A retrospective multicentre cohort study. Settings Four French ENT paediatric departments. Participants A total of 260 under 18 years old admitted for acute mastoiditis were included. Initial imaging was reviewed to focus on complicated mastoiditis and 52 OLST were identified. Children were then divided into two groups according to bacteriological results: 28 in the “OLST Fusobacterium group” and 24 in the “OLST other bacteria group”. Results There was a significant association between F necrophorum and OLST (P < .001). When compared to the OLST other bacteria group, children in the OLST Fusobacterium group were significantly younger (61 months vs 23 months, P < .01) and had a more severe clinical presentation: higher CRP (113 mg/L vs 175.7 mg/L, P = .02) and larger subperiosteal abscess (14 mm vs 21 mm, P < .01). Medical management was also more intensive in the OLST Fusobacterium group than in the OLST other bacteria group: increased number of conservative surgeries (66.7% vs 92.9%, P = .03) and longer hospital stay (13.7 days vs 19.8 days, P = .02). At the end of follow‐up, the clinical course was good in both groups without any neurological sequelae. Conclusions Thrombotic complications are very frequent in case of Fusobacterium mastoiditis and clinicians should be aware of the initial severity of the clinical presentation. Under appropriate management, the clinical course of Fusobacterium OLST is as good as that of other bacterial otogenic thrombosis.

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“…Kulak infeksiyonlarında da benzer şekilde nadir rastlanan bakteri ve mantar türle-rinin sıklığının artmakta olduğu söylenebilir. Son yıllarda yapılan bildirilerde, Alcaligenes xyloxidans (19) , Fusobacterium necrophorum (5) ve Massilia spp. (13) gibi bakterilerin yanı sıra; Scedosporiuma piospermum (3) , Malessezia sympodialis (4) ve Phialemonium spp.…”

Section: Discussionunclassified

Determination of the Causative Agents and Antimicrobial Susceptibility in Otitis Externa and Otitis Media Patients

Borsa¹,

Kaplan²,

Aldağ³

et al. 2016

Ankem Derg

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ÖZET Kulak infeksiyonları, başta çocuklar olmak üzere tüm yaş gruplarını etkileyebilen ve toplumda sık görülen infeksiyonlardır. Otitis eksterna (OE), 4) OE, 44'ü (% 37) OM ön tanılı hastalar oldukları görülmüştür. Ayrıca kültür pozitif OM hastalarının büyük çoğunluğunun (% 81.4) kronikleşmiş vakalar olması dikkat çekmiştir. OE tanısı alan 76 hastada en sık bulgular ağrı (% 97), işitme kaybı (% 96), kulak akıntısı (% 96), dış kulak yolunda ödem ve daralma (% 96) olarak saptanmıştır. OM tanısı alan 42 hastada en sık rastlanan bulgular ise kulak zarında perforasyon (% 100), ağrı (% 94), kulak akıntısı (% 94), ateş (% 69) ve işitme kaybı (% 54) olarak kaydedilmiştir. Kültür pozitif olan 76 OE hastamızdan izole edilen mikroorganizmalardan ikisi Anahtar sözcükler: etken mikroorganizmalar, kulak infeksiyonu, otitis eksterna, otitis media, Pseudomonas aeruginosa SUMMARY Determination of the Causative Agents and Antimicrobial Susceptibility in Otitis Externa and Otitis Media Patients Ear infections may affect almost all age groups, besides being among the most common human infections. Otitis externa (OE) is the inflammation of external auditory canal. Disease is usually seen during summer season, and may cause severe complications if left untreated. The most common causative agents are Pseudomonas aeruginosa and Staphylococcus aureus. Fungi, particularly Aspergillus and Candida species, may also cause the disease. Otitis media (OM) is characterized with pain, inflammation and effusion in the middle ear. Recurrent ear discharge and tympanic membrane perforation are also common findings particularly in patients with chronic infection. The most common causative agents are Streptococcus pneumoniae and Haemophilus influenzae, but the number of cases caused by these strains have been decreasing due to the effective vaccination programmes. P.aeruginosa, S.aureus, and enteric Gram negative bacteria are the most common microorganisms isolated in chronic OM cases.In

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Fusobacterium necrophorum, an emerging pathogen of otogenic and paranasal infections?

Cited by 39 publications

References 31 publications

Infections caused by Fusobacterium in children: a 14-year single-center experience

Infections caused by Fusobacterium in children: a 14-year single-center experience

Fusobacterium necrophorum, a major provider of sinus thrombosis in acute mastoiditis: A retrospective multicentre paediatric study

Determination of the Causative Agents and Antimicrobial Susceptibility in Otitis Externa and Otitis Media Patients

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