In this study, we designed aptamer-gated nanocapsules for the specific targeting of cargo to bacteria with controlled release of antibiotics based on aptamer-receptor interactions. Aptamer-gates caused a specific decrease in minimum inhibitory concentration (MIC) values of vancomycin for Staphylococcus aureus when mesoporous silica nanoparticles (MSNs) were used for bacteria-targeted delivery.

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SiOC ceramics were fabricated by a simple technique to obtain high surface area (reaching 774 m 2 /g) hierarchical porosity. • Porous SiOC material were found to be biocompatible with less hemolysis than MCM-41. • The loading capacity and the release kinetics of cargo loaded SiOC were better than that of MCM-41. • It was demonstrated that hierarchical porosity ceramic can be used to carry different sized drug molecules. • The antimicrobial activity tests show that SiOC performs better than MCM-41 in improving bactericidal activity.

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