Inhibitory effects of aptamer targeted teicoplanin encapsulated PLGA nanoparticles for Staphylococcus aureus strains

Uçak, Samet; Sudağıdan, Mert; Borsa, Barış Ata; Mansuroğlu, Banu; Özalp, Veli Cengiz

doi:10.1007/s11274-020-02845-y

Cited by 36 publications

(22 citation statements)

References 41 publications

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“… 38 Recent reported that S-nitrosoglutathione, Platensimycin or teicoplanin-PLGA nanoparticles as an ideal nanoparticles formulation for the treatment of MRSA-infected cutaneous wounds. 9 , 37 , 39 And PLGA nanoparticles have non-toxic characteristics of bio-composite to normal tissue or cell line. 40 , 41 …”

Section: Discussionmentioning

confidence: 99%

Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

Wu¹,

Dong²,

Du³

et al. 2021

IJN

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Introduction Topical agents typically remain in the wound site for time duration that are too short to effectively eradicate MRSA tradition formation of BZK that can be maintained within the wound site for longer time periods, should be more effective. Methods The novel chitosan and poly (D,L-lactide-co-glycoside) nanoparticles loaded with benzalkonium bromide (BZK) were designed, for the promotion wound healing after MRSA infection. The physical characterization of these nanoparticles, as well as their antibacterial activity in vitro, release profile in simulated wound fluid, cell toxicity, anti-biofilm activity, and their ability to improve the skin wound healing in a mouse model were also studied. Results These novel nanoparticles were found to have a significant antibacterial activity ( p <0.01), both in vitro and in vivo test. The stronger anti-biofilm ability of the nanoparticles to inhibit the formation of bacterial biofilms, at a concentration of 3.33 μg/mL, and clear existing bacterial biofilms, at a concentration of 5 mg/mL, compared with its water solution. In addition, significant damage to bacterial cell walls also was found, providing insight into the mechanism of antibacterial activity. Conclusion Taken together, these results demonstrated the ability of BZK-loaded nanoparticles in the promotion of skin wound healing with MRSA infection. The current findings open a new avenue for nanomedicine development and future clinical applications in the treatment of wounds.

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Section: Discussionmentioning

confidence: 99%

Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

Wu¹,

Dong²,

Du³

et al. 2021

IJN

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“…For instance, Ucak et al investigated the antibacterial effect of teicoplanin-containing PLGA nanoparticles functionalized with S. aureus-specific aptamers [130]. Moreover, Deepika et al synthesized PEG-PLGA nanoparticles for the co-delivery of rutin, a natural drug, and benzamide, a synthetic compound [131].…”

Section: Antibacterial Nanoparticlesmentioning

confidence: 99%

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

et al. 2021

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Despite the many advancements in the pharmaceutical and medical fields and the development of numerous antimicrobial drugs aimed to suppress and destroy pathogenic microorganisms, infectious diseases still represent a major health threat affecting millions of lives daily. In addition to the limitations of antimicrobial drugs associated with low transportation rate, water solubility, oral bioavailability and stability, inefficient drug targeting, considerable toxicity, and limited patient compliance, the major cause for their inefficiency is the antimicrobial resistance of microorganisms. In this context, the risk of a pre-antibiotic era is a real possibility. For this reason, the research focus has shifted toward the discovery and development of novel and alternative antimicrobial agents that could overcome the challenges associated with conventional drugs. Nanotechnology is a possible alternative, as there is significant evidence of the broad-spectrum antimicrobial activity of nanomaterials and nanoparticles in particular. Moreover, owing to their considerable advantages regarding their efficient cargo dissolving, entrapment, encapsulation, or surface attachment, the possibility of forming antimicrobial groups for specific targeting and destruction, biocompatibility and biodegradability, low toxicity, and synergistic therapy, polymeric nanoparticles have received considerable attention as potential antimicrobial drug delivery agents. In this context, the aim of this paper is to provide an up-to-date overview of the most recent studies investigating polymeric nanoparticles designed for antimicrobial therapies, describing both their targeting strategies and their effects.

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“…Another advantage of an aptamer-based targeted delivery system is that it can delay the evolution of resistance and improve the efficiency of the antimicrobials on already resistant pathogens. Ucak et al used Staphylococcus aureus-specific aptamer to functionalize methicillin, which is an antibiotic for serious infectious caused by Gram-positive bacteria ( Ucak et al, 2020 ). By limiting the amount and dosage during therapy, they proved that the novel delivery system was significantly effective in reducing minimum inhibitory concentration (MIC) values.…”

Section: Application Of Aptamers In Infectious Diseases Treatmentmentioning

confidence: 99%

Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases

Xin

Zhou

et al. 2021

Front. Bioeng. Biotechnol.

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Infectious diseases are considered as a pressing challenge to global public health. Accurate and rapid diagnostics tools for early recognition of the pathogen, as well as individualized precision therapy are essential for controlling the spread of infectious diseases. Aptamers, which were screened by systematic evolution of ligands by exponential enrichment (SELEX), can bind to targets with high affinity and specificity so that have exciting potential in both diagnosis and treatment of infectious diseases. In this review, we provide a comprehensive overview of the latest development of SELEX technology and focus on the applications of aptamer-based technologies in infectious diseases, such as targeted drug-delivery, treatments and biosensors for diagnosing. The challenges and the future development in this field of clinical application will also be discussed.

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Inhibitory effects of aptamer targeted teicoplanin encapsulated PLGA nanoparticles for Staphylococcus aureus strains

Cited by 36 publications

References 41 publications

Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

Targeting Antibacterial Effect and Promoting of Skin Wound Healing After Infected with Methicillin-Resistant Staphylococcus aureus for the Novel Polyvinyl Alcohol Nanoparticles

Polymeric Nanoparticles for Antimicrobial Therapies: An up-to-date Overview

Systematic Evolution of Ligands by Exponential Enrichment Technologies and Aptamer-Based Applications: Recent Progress and Challenges in Precision Medicine of Infectious Diseases

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