Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study

Eisele, Yannick; Mallea, Patrick M.; Gigic, Biljana; Stephens, W. Zac; Warby, Christy A.; Buhrke, Kate; Lin, Tengda; Boehm, Juergen; Schrotz‐King, Petra; Hardikar, Sheetal; Huang, Lyen C.; Pickron, T. Bartley; Scaife, Courtney L.; Viskochil, Richard; Koelsch, Torsten; Peoples, Anita R.; Pletneva, Maria; Bronner, Mary P.; Schneider, Martin; Ulrich, Alexis; Swanson, Eric A.; Toriola, Adetunji T.; Shibata, David; Li, Christopher I.; Siegel, Erin M.; Figueiredo, Jane C.; Janssen, Klaus-Peter; Hauner, Hans; Round, June L.; Ulrich, Cornelia M.; Holowatyj, Andreana N.; Ose, Jennifer

doi:10.1016/j.clcc.2021.02.007

Cited by 18 publications

(10 citation statements)

References 36 publications

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“…It has also been reported that Fn may encode virulence factors, such as FadA, Fap2, and MORN2 proteins, to induce CRC development ( Ranjbar et al., 2021 ). Consistent with these lines of experimental evidence, clinical studies demonstrate that the abundance of Fn in CRC tissues is significantly increased compared with the adjacent normal tissues, and a high prevalence of Fn is associated with advanced stage, metastasis, recurrence, and short OS of CRC patients ( Eisele et al., 2021 ; Mima et al., 2016 ; Serna et al., 2020 ; Yamamoto et al., 2021 ).Therefore, Fn, as a potential oncobacterium, may be helpful for the early detection and prognostic prediction of CRC.…”

Section: Introductionmentioning

confidence: 56%

Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Zhang

Gui

et al. 2022

iScience

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Section: Introductionmentioning

confidence: 56%

Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Zhang

Gui

et al. 2022

iScience

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“…Over 100 epidemiological studies have been identified in the primary search specifically mentioning F. nucleatum in the abstract. Supplementary Table 10 summarizes the characteristics and main outcomes of 42 of these epidemiological studies which met the eligibility criteria, most of which comparing F. nucleatum presence/abundance in feces from CRC patients versus healthy controls and of tumor tissue versus adjacent normal tissue ( Supplementary Table 10 ; Castellarin et al, 2012 ; Flanagan et al, 2014 ; Fukugaiti et al, 2015 ; Ito et al, 2015 ; Mira-Pascual et al, 2015 ; Wang et al, 2016 ; Xie and Fang, 2016 ; Yu et al, 2016 , 2017 ; Amitay et al, 2017 ; Drewes et al, 2017 ; Eklöf et al, 2017 ; Liang et al, 2017 , 2021 ; Scott et al, 2017 ; Suehiro et al, 2017 ; Yamamura et al, 2017 ; Yoon et al, 2017 ; Hale et al, 2018 ; Hsieh et al, 2018 ; Kwong et al, 2018 ; Repass, 2018 ; Russo et al, 2018 ; Tsuchiya et al, 2018 ; Bundgaard-Nielsen et al, 2019 ; Butt et al, 2019 ; Chen et al, 2019 ; De Carvalho et al, 2019 ; Kageyama et al, 2019 ; Saito et al, 2019 ; Tunsjø et al, 2019 ; Yachida et al, 2019 ; Zhang et al, 2019 ; Alkharaan et al, 2020 ; Boehm et al, 2020 ; Gantuya et al, 2020 ; Kashani et al, 2020 ; Reynolds et al, 2020 ; Eisele et al, 2021 ; Kawasaki et al, 2021 ; Kurt and Yumuk, 2021 ; Pignatelli et al, 2021 ). Two meta-analyses published in 2020 reported pooled ORs of 8.3 for detection of F. nucleatum in colorectal specimens (feces/mucosa/tissue) and being diagnosed with CRC, and 10.06 for detection of F. nucleatum in CRC tissue versus healthy tissue from controls ( Supplementary Table 7 ; Gethi...…”

Section: Resultsmentioning

confidence: 99%

Bacterial and Parasitic Pathogens as Risk Factors for Cancers in the Gastrointestinal Tract: A Review of Current Epidemiological Knowledge

et al. 2021

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The oncogenic potential of viral infections is well established and documented for many years already. However, the contribution of (commensal) bacteria and parasites to the development and progression of cancers has only recently gained momentum, resulting in a rapid growth of publications on the topic. Indeed, various bacteria and parasites have been suggested to play a role in the development of gastrointestinal cancer in particular. Therefore, an overview of the current epidemiological knowledge on the association between infections with bacteria and parasites and cancers of the gastrointestinal tract is needed. In this review, we summarized the methodological characteristics and main results of epidemiological studies investigating the association of 10 different bacteria (Bacteroides fragilis, Campylobacter spp., Clostridium spp., Enterococcus faecalis, Escherichia coli, Fusobacterium nucleatum, Porphyromonas gingivalis, non-typhoidal Salmonella, Salmonella Typhi, and Streptococcus spp.) and three parasites (Cryptosporidium spp., Schistosoma spp., and Strongyloides stercoralis) with gastrointestinal cancer. While the large body of studies based on microbiome sequencing provides valuable insights into the relative abundance of different bacterial taxa in cancer patients as compared to individuals with pre-malignant conditions or healthy controls, more research is needed to fulfill Koch’s postulates, possibly making use of follow-up data, to assess the complex role of bacterial and parasitic infections in cancer epidemiology. Studies incorporating follow-up time between detection of the bacterium or parasite and cancer diagnosis remain valuable as these allow for estimation of cause-effect relationships.

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“… 33 Cohort studies in multiple countries have confirmed that CRC patients have an increased abundance of F. nucleatum in feces, 34 and CRC patients with a higher fecal abundance of F. nucleatum had a 3- to 5-fold increased risk of being diagnosed with rectal cancer compared to colon cancer, specifically right-sided colon cancer. 35 However, feces are easily affected by diet, bowel habits, and other factors, 36 and the abundance of bacteria is greatly affected by the sampling process. Considering that microbiota in direct contact with epithelial cells are likely to influence the progression of CRC, microbiome analysis of tissue samples can provide highly useful data.…”

Section: Discussionmentioning

confidence: 99%

“…Another reason may be the inhomogeneity of F. nucleatum distribution, consistent with a previous study showing that the abundance of F. nucleatum varies at different sampling sites even in the same tumor tissues 40 and tumor site. 35 A high load of intratumoral F. nucleatum is associated with a poor response to chemotherapy. 16 , 32 In this study, Kaplan‒Meier analysis showed that F. nucleatum in CRC is associated with patient DFS, and the DFS in the F. nucleatum -negative group was significantly longer than that in the F. nucleatum -positive group.…”

Section: Discussionmentioning

confidence: 99%

Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis

Xie¹,

Jiao²,

Zeng³

et al. 2022

CMAR

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Objective Both genetic and microbial factors play important roles in colorectal cancer (CRC) development. The effects of Fusobacterium nucleatum ( F. nucleatum ) and microsatellite instability (MSI) on CRC prognosis require more clinical evidence. We aimed to investigate the role of F. nucleatum and MSI as biomarkers in predicting the prognosis of CRC. Methods CRC patients in various TNM stages were enrolled. MSI status and F. nucleatum were detected by immunohistochemical staining of formalin-fixed paraffin-embedded (FFPE) specimens. The associations between MSI status and F. nucleatum and clinical parameters were analyzed. Results MSI tumors were more frequently observed in the colon than in the rectum. Cancerous tissues had higher levels of F. nucleatum than adjacent noncancerous tissues. There were no significant differences in F. nucleatum abundance in different age, sex, tumor stage, location, and tumor marker groups. MSI status was associated with tumor location and stage. Survival analyses revealed that disease-free survival (DFS) was significantly longer in the F. nucleatum -negative, younger age, and TNM stage I–II groups (p< 0.05), and age, advanced TNM stage (III and IV), and F. nucleatum status were independent factors for poor prognosis. Multivariate Cox regression and receiver operating characteristic (ROC) curve analyses showed that conventional tumor biomarkers of CRC had more prognostic value than F. nucleatum and MSI. Conclusion Age, advanced TNM stage, and F. nucleatum positivity were independent factors of poor prognosis, suggesting that F. nucleatum and MSI may contribute to the identification of new strategies for the prevention and treatment of CRC.

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Fusobacterium nucleatum and Clinicopathologic Features of Colorectal Cancer: Results From the ColoCare Study

Cited by 18 publications

References 36 publications

Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Salivary Fusobacterium nucleatum serves as a potential biomarker for colorectal cancer

Bacterial and Parasitic Pathogens as Risk Factors for Cancers in the Gastrointestinal Tract: A Review of Current Epidemiological Knowledge

Clinical Significance of Fusobacterium nucleatum and Microsatellite Instability in Evaluating Colorectal Cancer Prognosis

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