Fusobacterium nucleatum load in MSI colorectal cancer subtypes

Ono, Tomoyuki; Yamaguchi, Tatsuro; Takao, Misato; Kojika, Ekumi; Iijima, Takeru; Horiguchi, Shinichiro

doi:10.1007/s10147-022-02218-5

Cited by 5 publications

(3 citation statements)

References 21 publications

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“… Tahara et al (2014) identified high numbers of F. nucleatum and pan- Fusobacterium associated with CIMP positivity, and the phenotype was analyzed using seven markers ( ER , SFRP1 , MYOD1 , MGMT , SLC16A2 , SPOCK2 , and N33 ) in CRC tissues. Moreover, concordant results have been reported by other authors who employed different markers for CIMP identification ( Ito et al, 2015 ; Mima et al, 2015 ; Lee et al, 2018 ; Li J. et al, 2019 ; Ono et al, 2022 ), but no significant association was reported by Park et al, 2017 . They analyzed eight markers for CIMP diagnosis ( MLH1 , NEUROG1 , CRABP1 , CACNA1G , CDKN2A , IGF2 , SOCS1 , and RUNX3 ), and only high F. nucleatum was significantly associated with CDKN2A methylation in CRC tissues with high MSI.…”

Section: Dna Methylation and Microbiotasupporting

confidence: 82%

Microbiota composition and its impact on DNA methylation in colorectal cancer

Gutierrez-Angulo,

Ayala-Madrigal,

Moreno-Ortiz

et al. 2023

Front. Genet.

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Colorectal cancer is a complex disease resulting from the interaction of genetics, epigenetics, and environmental factors. DNA methylation is frequently found in tumor suppressor genes to promote cancer development. Several factors are associated with changes in the DNA methylation pattern, and recently, the gastrointestinal microbiota could be associated with this epigenetic change. The predominant phyla in gut microbiota are Firmicutes and Bacteroidetes; however, an enrichment of Bacteroides fragilis, Fusobacterium nucleatum, and Streptococcus bovis, among others, has been reported in colorectal cancer, although the composition could be influenced by several factors, including diet, age, sex, and cancer stage. Fusobacterium nucleatum, a gram-negative anaerobic bacillus, is mainly associated with colorectal cancer patients positive for the CpG island methylator phenotype, although hypermethylation in genes such as MLH1, CDKN2A, MTSS1, RBM38, PKD1, PTPRT, and EYA4 has also been described. Moreover, Hungatella hathewayi, a gram-positive, rod-shaped bacterium, is related to hypermethylation in SOX11, THBD, SFRP2, GATA5, ESR1, EYA4, CDX2, and APC genes. The underlying epigenetic mechanism is unclear, although it could be implicated in the regulation of DNA methyltransferases, enzymes that catalyze the transfer of a methyl group on cytosine of CpG sites. Since DNA methylation is a reversible event, changes in gut microbiota could modulate the gene expression through DNA methylation and improve the colorectal cancer prognosis.

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Section: Dna Methylation and Microbiotasupporting

confidence: 82%

Microbiota composition and its impact on DNA methylation in colorectal cancer

Gutierrez-Angulo,

Ayala-Madrigal,

Moreno-Ortiz

et al. 2023

Front. Genet.

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“… 24 In consensus with our findings, high intra-tumoral F. nucleatum abundance have been reported in dMMR/MSI-H CRC, including those of hereditary nature. 18 , 50 , 51 , 52 To our knowledge, this study is the first to detect enriched Fusobacterium in LS-CRC fecal sample.…”

Section: Discussionmentioning

confidence: 74%

“… 15 , 16 Studies of patients with dMMR CRC and MSI-H CRC have reported distinct Fusobacterium enrichment in dMMR CRC gut microbiota and MSI-H CRC tissue samples. 17 , 18 , 19 A study on patients with LS and colorectal adenoma reported similar gut microbiota dysbiosis in LS adenoma and sporadic CRC but no Fusobacterium enrichment. 20 Several other studies have also reported distinct gut microbiota compositions between patients with and without LS, as well as between patients with LS and a CRC history and those without any CRC history.…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer

Salim,

Mizutani,

Shiba

et al. 2024

iScience

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Molecular symphonies and signalling pathways orchestrated by the gut microbiome in metastatic colorectal cancer (mCRC); a state-of-the-art review

Fatemi,

Jahdkaran,

Mirbahari

et al. 2024

Expert Rev. Mol. Med.

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The role of oncobiosis, characterized by dysregulated microbial ecosystems associated with cancer, has been increasingly acknowledged in promoting the metastasis and dissemination of tumour cells. A comprehensive understanding of the complex interactions between the gut microbiome and metastatic colorectal cancer (mCRC) presents promising avenues for the development of innovative therapeutic approaches centred around modulating the gut microbiome to prevent or hinder metastatic spread. In this comprehensive review, we aim to provide a molecularly focused summary of the implications of the human gut microbiome and microbial metabolites in the initiation and advancement of mCRC. By elucidating these intricate mechanisms, we strive to establish a foundation for future research and the design of novel interventions targeting the gut microbiome to combat this devastating disease.

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Fusobacterium nucleatum load in MSI colorectal cancer subtypes

Cited by 5 publications

References 21 publications

Microbiota composition and its impact on DNA methylation in colorectal cancer

Microbiota composition and its impact on DNA methylation in colorectal cancer

Fusobacterium species are distinctly associated with patients with Lynch syndrome colorectal cancer

Molecular symphonies and signalling pathways orchestrated by the gut microbiome in metastatic colorectal cancer (mCRC); a state-of-the-art review

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