Future directions of forensic DNA databases

Ge, Jianye; Sun, Hongyu; Li, Haiyan; Liu, Chao; Yan, Jiangwei; Budowle, Bruce

doi:10.3325/cmj.2014.55.163

Cited by 46 publications

(57 citation statements)

References 8 publications

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“…Y chromosome STR loci have been used to assist forensic investigation for almost two decades . Y‐STR loci are commonly used in forensic investigations, primarily because most of the crimes are committed by males and the Y chromosome can be used to trace male lineages due to its unique genetic inheritance from father to sons. Y‐STR loci also serve as a supplementary tool for relationship‐testing cases, such as distant relationship identifications.…”

Section: Introductionmentioning

confidence: 99%

“…Y‐STR loci can provide ancestry information with high accuracy . In geographical areas with limited immigration, a Y‐STR profile can efficiently narrow down the search for perpetrators by first screening the male lineages and then investigating the individuals of the Y haplotype matched families .…”

Section: Introductionmentioning

confidence: 99%

“…With this database, potential sources of a DNA sample were searched by first screening families' Y‐STR haplotype(s) and then developing investigative leads of the individuals of the Y haplotype‐matched families. A large number of cases have been solved in an expeditious manner with the use of this Y‐STR database .…”

Section: Introductionmentioning

confidence: 99%

“…With this database, potential sources of a DNA sample were searched by first screening families' Y-STR haplotype(s) and then developing investigative leads of the individuals of the Y haplotype-matched families. A large number of cases have been solved in an expeditious manner with the use of this Y-STR database [10]. Unlike the haplotype comparison and possible frequency estimation of the mitochondrial DNA, which allow a certain degree of mismatch due to heteroplasmy and potential mutation, the Y-STR haplotype frequency usually has not considered mismatch as the mutation rates of Y-STR loci are relatively low (i.e.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED: A convenient guideline to determine if two Y‐STR profiles are from the same lineage

Liu

Mulero

et al. 2016

Electrophoresis

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Y chromosome STR loci are used in forensics primarily for identification purposes by determining the male lineages. The Henan province in China has established a large Y-STR (>200 000 profiles) database for criminal investigations. A large proportion of the Y-STR profiles in the database were generated using either the Applied Biosystems Yfiler(ۛ) or Yfiler(ۛ) Plus PCR Amplification kits. The additional loci in the Yfiler Plus kit as compared to the Yfiler kit results in a concomitant cumulative mutation rate increase across the loci. Therefore, in those cases when two profiles have one to a few mismatched loci, it is difficult to determine if they are from the same lineage. In this study, 7405 unrelated male profiles were manually selected from the database. Analysis showed higher power of discrimination than the corresponding Yfiler haplotypes. Further, the distributions of the number of mismatched loci and the mismatched steps were generated for father-son, grandfather-grandson, uncle-nephew, and cousins (i.e. one, two, three, and four meioses, respectively) by exhaustive pairwise comparison of the unrelated profiles using a dynamic programming approach. The same distributions were generated for unrelated pairs with mutation rates of the loci. With the distributions, the false negative and false positive rates were determined. Two Yfiler profiles with ≤2 mismatched loci or ≤2 steps are more likely from the same lineage than unrelated lineages, and two Yfiler Plus profiles with ≤4 mismatched loci or ≤5 mismatched steps are more likely from the same lineage.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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RETRACTED: A convenient guideline to determine if two Y‐STR profiles are from the same lineage

Liu

Mulero

et al. 2016

Electrophoresis

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“…There are over 50 operational national forensic DNA databases, with some of the largest found in China and the United States [8]. Every database however, may vary in terms of which profiles are eligible for entering the databank (e.g.…”

Section: Dna Elimination Database For Crime Scene Workersmentioning

confidence: 99%