Future of additive manufacturing in healthcare

Ghomi, Erfan Rezvani; Khosravi, Fatemeh; Neisiany, Rasoul Esmaeely; Singh, Sunpreet; Ramakrishna, Seeram

doi:10.1016/j.cobme.2020.100255

Cited by 83 publications

(41 citation statements)

References 43 publications

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“…Over the past few years, 3D bioprinting has become extremely popular as a way to fabricate micro physiological devices, biological tissues, preferable vascular‐like networks, and implantable scaffolds 105,106 . Before bioprinting custom‐made 3D structures, they have to be first computationally designed after advanced magnetic resonance imaging or computed tomography.…”

Section: The Potential Of 3d Printingmentioning

confidence: 99%

Collagen‐based biomaterials for biomedical applications

et al. 2021

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Collagen is an insoluble fibrous protein that composes the extracellular matrix in animals. Although collagen has been used as a biomaterial since 1881, the properties and the complex structure of collagen are still extensive study subjects worldwide. In this article, several topics of importance for understanding collagen research are reviewed starting from its historical milestones, followed by the description of the collagen superfamily and its complex structures, with a focus on type I collagen. Subsequently, some of the superior properties of collagen‐based biomaterials, such as biocompatibility, biodegradability, mechanical properties, and cell activities, are pinpointed. These properties make collagen applicable in biomedicine, such as wound healing, tissue engineering, surface coating of medical devices, and skin supplementation. Moreover, some antimicrobial strategies and the general host tissue responses regarding collagen as a biomaterial are presented. Finally, the current status and clinical application of the three‐dimensional (3D) printing techniques for the fabrication of collagen‐based scaffolds and the reconstruction of the human heart's constituents, such as capillary structures or even the entire organ, are discussed. Besides, an overall outlook for the future of this unique biomaterial is provided.

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Section: The Potential Of 3d Printingmentioning

confidence: 99%

Collagen‐based biomaterials for biomedical applications

et al. 2021

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“…Another application of PLA in the biomedical section is for tissue engineering (TE). One of the most applicable PLA forms in TE is three-dimensional (3D) porous scaffolds used for cell culturing applications, such as cardiovascular diseases [63]. The 3D PLA structure is affordable by electrospinning and 3D printing for patient-customized products [64].…”

Section: Photodegradation Of the Samplesmentioning

confidence: 99%

The Life Cycle Assessment for Polylactic Acid (PLA) to Make It a Low-Carbon Material

et al. 2021

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The massive plastic production worldwide leads to a global concern for the pollution made by the plastic wastes and the environmental issues associated with them. One of the best solutions is replacing the fossil-based plastics with bioplastics. Bioplastics such as polylactic acid (PLA) are biodegradable materials with less greenhouse gas (GHG) emissions. PLA is a biopolymer produced from natural resources with good mechanical and chemical properties, therefore, it is used widely in packaging, agriculture, and biomedical industries. PLA products mostly end up in landfills or composting. In this review paper, the existing life cycle assessments (LCA) for PLA were comprehensively reviewed and classified. According to the LCAs, the energy and materials used in the whole life cycle of PLA were reported. Finally, the GHG emissions of PLA in each stage of its life cycle, including feedstock acquisition and conversion, manufacturing of PLA products, the PLA applications, and the end of life (EoL) options, were described. The most energy-intensive stage in the life cycle of PLA is its conversion. By optimizing the conversion process of PLA, it is possible to make it a low-carbon material with less dependence on energy sources.

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“…Multiple novel platforms are gaining interest in elucidating sophisticated solutions to treat cancer with emerging nanotechnology connecting immune response (Waldman et al, 2020). Nanotechnology interventions can also augment flexible biomaterials with designs related to additive manufacturing (Ghomi et al, 2020). However, with technical advancements, control over physicochemical parameters such as size, surface functionalization, shape and, charge paramount stimuli response as well as loading efficiency of nanomaterials.…”

Section: Classification and Characteristics Of Nanomaterials For Cancer Immunotheranosticmentioning

confidence: 99%

Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics

Khan

Dias²,

Neekhra

et al. 2021

Front. Chem.

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Cancer has been widely investigated yet limited in its manifestation. Cancer treatment holds innovative and futuristic strategies considering high disease heterogeneity. Chemotherapy, radiotherapy and surgery are the most explored pillars; however optimal therapeutic window and patient compliance recruit constraints. Recently evolved immunotherapy demonstrates a vital role of the host immune system to prevent metastasis recurrence, still undesirable clinical response and autoimmune adverse effects remain unresolved. Overcoming these challenges, tunable biomaterials could effectively control the co-delivery of anticancer drugs and immunomodulators. Current status demands a potentially new approach for minimally invasive, synergistic, and combinatorial nano-biomaterial assisted targeted immune-based treatment including therapeutics, diagnosis and imaging. This review discusses the latest findings of engineering biomaterial with immunomodulating properties and implementing novel developments in designing versatile nanosystems for cancer theranostics. We explore the functionalization of nanoparticle for delivering antitumor therapeutic and diagnostic agents promoting immune response. Through understanding the efficacy of delivery system, we have enlightened the applicability of nanomaterials as immunomodulatory nanomedicine further advancing to preclinical and clinical trials. Future and present ongoing improvements in engineering biomaterial could result in generating better insight to deal with cancer through easily accessible immunological interventions.

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Future of additive manufacturing in healthcare

Cited by 83 publications

References 43 publications

Collagen‐based biomaterials for biomedical applications

Collagen‐based biomaterials for biomedical applications

The Life Cycle Assessment for Polylactic Acid (PLA) to Make It a Low-Carbon Material

Designing and Immunomodulating Multiresponsive Nanomaterial for Cancer Theranostics

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