2022
DOI: 10.1213/ane.0000000000005966
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Future of Perioperative Precision Medicine: Integration of Molecular Science, Dynamic Health Care Informatics, and Implementation of Predictive Pathways in Real Time

Abstract: Conceptually, precision medicine is a deep dive to discover disease origin at the molecular or genetic level, thus providing insights that allow clinicians to design corresponding individualized patient therapies. We know that a disease state is created by not only certain molecular derangements but also a biologic milieu promoting the expression of such derangements. These factors together lead to manifested symptoms. At the level of molecular definition, every average, “similar” individual stands to be “diss… Show more

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Cited by 4 publications
(6 citation statements)
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“…Also, a meta‐analysis of epigenome‐wide association studies of over 8000 patients was able to identify specific patterns of DNA methylation at genetic loci underlying low‐grade inflammation associated with chronic disease [ 93 ]. Given both the phenotypic complexity of postoperative systemic inflammatory dysregulation and the potential heterogeneity of peri‐operative supplemental corticosteroid actions, integrated multi‐omic analyses examining the genome, metabolome, proteome and cellular networks are required to further define predictive variants that are interacting to significantly impact on clinical outcomes [ 94 , 95 , 96 ].…”
Section: Targeting Patientsmentioning
confidence: 99%
“…Also, a meta‐analysis of epigenome‐wide association studies of over 8000 patients was able to identify specific patterns of DNA methylation at genetic loci underlying low‐grade inflammation associated with chronic disease [ 93 ]. Given both the phenotypic complexity of postoperative systemic inflammatory dysregulation and the potential heterogeneity of peri‐operative supplemental corticosteroid actions, integrated multi‐omic analyses examining the genome, metabolome, proteome and cellular networks are required to further define predictive variants that are interacting to significantly impact on clinical outcomes [ 94 , 95 , 96 ].…”
Section: Targeting Patientsmentioning
confidence: 99%
“…In this month’s issue of Anesthesia & Analgesia , Nirvik and Kertai 4 present a futuristic vision of perioperative precision medicine. These authors persuasively highlight the predictive, preventive, personalized, participatory, and pertinent facets of perioperative precision medicine.…”
mentioning
confidence: 99%
“…Nirvik and Kertai 4 herein speak to the novel “n-of-1” trial, in which the individual patient, receiving customized therapy, is the focus of the clinical research testing a study hypothesis. A chronic condition with repetitive and cyclical use of the same therapeutic intervention is a good example.…”
mentioning
confidence: 99%
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