Future Perspectives in Nerve Repair and Regeneration

Tos, Pierluigi; Ronchi, Giulia; Geuna, Stefano; Battiston, Bruno

doi:10.1016/b978-0-12-420045-6.00008-0

Cited by 41 publications

(31 citation statements)

References 140 publications

(127 reference statements)

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“…Although usually not threatening the patient's life, nerve injuries represent a heavy social burden in terms of both long term disability and economic costs (Asplund et al, 2009;Rosberg et al, 2013). For this reason, growing efforts are dedicated to the development of effective treatment for peripheral nerve injuries which increase tissue regeneration and functional recovery and might be eventually translated to the patients for improving the clinical outcome (Tos et al, 2013, Griffin et al, 2013.…”

Section: Introductionmentioning

confidence: 99%

The sciatic nerve injury model in pre-clinical research

Geuna

2015

Journal of Neuroscience Methods

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117

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In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to be carried out in animal models due to the structural complexity of this organ which can be only partly simulated in vitro. The far most used experimental model is based on the injury of the sciatic nerve, the largest nerve trunk in mammals. In this paper, the potential application of the sciatic nerve injury model in pre-clinical research is critically reviewed. This paper is aimed at helping researchers in properly employing this in vivo model for the study of nerve repair and regeneration as well as interpreting the results in a clinical translation perspective.

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Section: Introductionmentioning

confidence: 99%

The sciatic nerve injury model in pre-clinical research

Geuna

2015

Journal of Neuroscience Methods

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117

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“…In spite of this, the distribution of brain function occurs in an organized manner, with each region having a predominance to carry out brain commands and, therefore, to assume a function for a given region. Considering this aspect, a brain injury leads to loss of functional capacity of the individual, according to its location and extent (11) . The region of the basal ganglia is an extremely specialized location that, in terms of motor function, has as its main function the maintenance of muscle tone and movement coordination, together with the cerebellar system (12) .…”

Section: Discussionmentioning

confidence: 99%

Dysfunctions of the stomatognathic system and vocal aspects in Fahr disease: case report

Santos

Fraga

Cardoso

2014

CoDAS

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The aim of this study is to report the case of a patient with Fahr's Disease in order to describe the main stomatognathic and vocal changes that can be found in individuals with this disease. In order to establish the diagnosis, an assessment of the conditions of orofacial motor system and speech production, as well the efficiency of swallowing, was realized. Based on these assessments, there were difficulties in coordinating and sustaining muscle during speech and presence of oropharyngeal dysphagia. Speech disorders found in Fahr's disease manifest themselves in complex and cover various aspects of phonological knowledge and the diseases that affect the basal ganglia have similar frames of speech-language disorders of the stomatognathic system, being able to present a picture of dysarthria.

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“…When the lesion causes substance loss, the two nerve stumps must be connected by a nerve guide in order to allow regenerating axons to bridge the gap [28,29]. The nerve guide can be represented by an autologous nerve segment (traditional autograft), e.g., from the sural nerve or by a non-nervous conduit [5,30].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits

Rochkind¹,

Mandelbaum-Livnat²,

StefaniaRaimondo³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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The repair of peripheral nerve traumatic lesions still represents a major cause of permanent motor and sensory impairment. In case of substance loss, a nerve guide should be used to bridge the proximal with the distal stump of the severed nerve. The effectiveness of hollow nerve guides is limited by the delay of axonal growth due to the absence of a regeneration substrate inside the conduit. To fasten up nerve regeneration, nerve guides should thus be enriched by a luminal filler. In this study, we investigated, in a 12-mm rat sciatic nerve defect experimental model, the effectiveness of chitosan-based conduits of different acetylation filled either with a hyaluronic acid gel (NVR gel) or with a magnetic fibrin hydrogel, in comparison with traditional autografts. Results showed that all types of artificial nerve conduits led to functional recovery not significantly different from autografts. By contrast, morphological and morphometrical analyses showed that the best results among nerve guides were found in medium degree of acetylation (DAII: ∼5%) chitosan conduits enriched with the NVR gel.

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Future Perspectives in Nerve Repair and Regeneration

Cited by 41 publications

References 140 publications

The sciatic nerve injury model in pre-clinical research

The sciatic nerve injury model in pre-clinical research

Dysfunctions of the stomatognathic system and vocal aspects in Fahr disease: case report

Peripheral Nerve Reconstruction Using Enriched Chitosan Conduits

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