The world has entered a human-dominated epoch, often referred to as the Anthropocene, where human activities are shaping local environments as well as the earth system. As a result, these activities potentially adversely affect one another, and quantification of their interactions is needed to support integrated decision making. My thesis quantifies whether sufficient agricultural production can be achieved under sustainable water management and climate change. Agricultural production, water resources and their interactions are quantified using the robust process-based hydrology-crop model VIC-WOFOST, which is a dynamic coupling of the Variable Infiltration Capacity (VIC) hydrological model and the WOrld FOod STudies (WOFOST) crop model. Using VIC-WOFOST, I first quantify present-day worldwide water use and the impact of sustainable water management on worldwide agricultural production. My results show that present-day human water use severely exceeds sustainable water use, and irrigation should be constrained under sustainable water management. These irrigation constraints would result in substantial reductions in worldwide agricultural production, in particular for croplands in the Indus basin, which contains almost all of Pakistan's agriculture. For the Indus basin, I subsequently assess the impacts of climate-change mitigation and agricultural adaptation on agricultural production and water use. In these regions, temperature increases under climate change and associated crop-heat stress adversely affect agricultural production, even though climate-change and elevated atmospheric carbon dioxide concentrations benefit water use. However, if appropriate agricultural adaptation measures are taken, sufficient agricultural production can be achieved in Pakistan for all but the highest population growth scenario, even under sustainable water management and climate change. My thesis clearly indicate the strong interactions between agriculture, water and climate and the opportunities of adaptation. This information contributes to integrated policies and decision making for both sufficient agricultural production and sustainable water management in the epoch of the Anthropocene.